Association between visual function and the integrity of residual ellipsoid zone in resolved central serous chorioretinopathy
Association between visual function and the integrity of residual ellipsoid zone in resolved central serous chorioretinopathy
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DOI：
10.1038/s41598-019-48825-7
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发表时间：
2019-08-27
影响因子：
4.6
通讯作者：
Obata, Ryo
中科院分区：
文献类型：
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作者：
Fujita, Asahi;Aoyama, Yurika;Obata, Ryo
中心性浆液性脉络膜视网膜病变（CSC）通常自发消退;然而，在某些患者中，它可能是慢性的，即使在浆液性视网膜脱离消退后，视力损害仍然存在。光学相干断层扫描（OCT）显示受损的感光细胞常表现为椭圆区（EZ）的破坏。在这项研究中，通过计算残留EZ的指数来量化EZ的完整性，该残留EZ在来自23名患有已解决CSC的患者的25只眼睛的二值化OCT图像上识别。为了估计残余EZ，研究了残余EZ与中央凹上的中心水平线的完整性（rEZc）和3 x 3 mm黄斑区域内的残余EZ的平均完整性（rEZave）。使用组内相关系数（ICC）评估该方法的评分者间可靠性。使用线性混合模型评估LogMAR VA与年龄、中央视网膜厚度、中央脉络膜厚度、rEZc和rEZave之间的关系。用MP-3微视野计测量视网膜敏感性，并对平均视网膜敏感性（MS）进行类似的分析。rEZc和rEZave的ICC值分别为0.938和0.979。rEZc与LogMAR VA显著相关（p = 0.039）。rEZave与MS显著相关（p < 0.001）。这些结果表明，残余EZ预测解决CSC的视觉功能的潜在有用性。
Central serous chorioretinopathy (CSC) usually resolves spontaneously; however, in some patients, it can be chronic and visual impairment remains even after resolution of the serous retinal detachment. The impaired photoreceptor cells often present with disrupted ellipsoid zone (EZ) on optical coherence tomography (OCT). In this study, the integrity of EZ was quantified by calculating the index of residual EZ, identified on binarized OCT images from 25 eyes of 23 patients with resolved CSC. To estimate residual EZ, integrity of residual EZ with the central horizontal line on the fovea (rEZc) and average integrity of residual EZ within 3 x 3-mm macular area (rEZave) were investigated. The interrater reliability of the method was assessed using the intraclass correlation coefficient (ICC). The relationship between LogMAR VA and age, central retinal thickness, central choroidal thickness, rEZc, and rEZave were evaluated using the linear mixed model. Retinal sensitivity was measured with the MP-3 microperimeter and similar analyses were iterated for mean retinal sensitivity (MS). ICC values were 0.938 with rEZc and 0.979 with rEZave. rEZc was significantly related to LogMAR VA (p = 0.039). rEZave was significantly related to MS (p < 0.001). These results suggested potential usefulness of residual EZ to predict visual function in resolved CSC.