Fibroblast growth factor-2
Fibroblast growth factor-2
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DOI：
10.1016/s1357-2725(99)00123-5
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发表时间：
2000-02-01
影响因子：
4
通讯作者：
Iozzo, RV
中科院分区：
文献类型：
--
作者：
Nugent, MA;Iozzo, RV
成纤维细胞生长因子-2（FGF-2）是一个与肝素和硫酸乙酰肝素结合并调节多种细胞功能的蛋白质大家族的成员。FGF-2刺激新血管的生长和发育（血管生成），这有助于几种疾病的发病机制（即，癌症、动脉粥样硬化）、正常伤口愈合和组织发育。FGF-2含有许多碱性残基（p19.6），并且由组织成三角嘧啶结构的12个反平行β-片层组成。FGF-2与表达为许多剪接变体的四种细胞表面受体结合。已发现FGF-2的许多生物学活性依赖于其受体的内在酪氨酸激酶活性和第二信使如促分裂原活化蛋白激酶。然而，大量证据表明细胞内FGF-2可能具有直接的生物学作用，特别是在细胞核内。此外，硫酸乙酰肝素蛋白聚糖已被证明可增强和抑制FGF-2活性。FGF-2活性可以通过改变硫酸乙酰肝素结合来操纵的可能性目前正在开发旨在调节内源性或施用的FGF-2活性的临床应用。(C)2000爱思唯尔科技有限公司版权所有。
Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins thatd1dt bind heparin and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i,e. cancer, atherosclerosis), normal wound healing and tissue development. FGF-2 contains a number of basic residues (pl 9.6) and consists of 12 anti-parallel beta-sheets organized into a trigonal pyrimidal structure. FGF-2 binds to four cell surface receptors expressed as a number of splice variants. Many of the biological activities of FGF-2 have been found to depend on its receptor's intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases, However, considerable evidence suggest that intracellular FGF-2 might have a direct biological role particularly within the nucleus. In addition, heparan sulfate proteoglycans have been demonstrated to enhance and inhibit FGF-2 activity. The possibility that FGF-2 activity can be manipulated through alterations in heparan sulfate-binding is currently being exploited in the development of clinical applications aimed at modulating either endogenous or administered FGF-2 activity. (C) 2000 Elsevier Science Ltd. All rights reserved.