The role of microbiota in allogeneic hematopoietic stem cell transplantation.
The role of microbiota in allogeneic hematopoietic stem cell transplantation.
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DOI：
10.1080/14712598.2021.1872541
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发表时间：
2021-08
影响因子：
4.6
通讯作者：
Jenq RR
中科院分区：
文献类型：
--
作者：
Chang CC;Hayase E;Jenq RR
同种异体造血干细胞移植（alloo - hsct）通常用于治疗各种良性和恶性血液系统疾病。急性移植物抗宿主病（GVHD）是同种异体造血干细胞移植后经常发生的危及生命的主要并发症。最近，表征微生物群的方法的改进使人们更清楚地认识到，在同种异体造血干细胞移植受体中，微生物组成的改变或生态失调是多么频繁和深刻，从而更好地解读微生物群与同种异体造血干细胞移植结果之间复杂的相互作用。本文综述了微生物群对同种异体造血干细胞移植结果影响的现有知识，包括微生物群衍生代谢物的影响，以及共生体和同种异体免疫应答之间的串扰。本文还总结了造血干细胞移植和移植相关手术对微生物群的影响，以及介入策略的最新进展。越来越多的文献表明，在接受同种异体造血干细胞移植的患者中，肠道微生物群的组成可以作为急性GVHD的风险和严重程度以及总生存率的预测性生物标志物。然而，支持这种关联的机制尚不清楚，调节微生物组以改善结果的临床策略尚未完全开发。目前尚不清楚提高同种异体造血干细胞移植疗效的机制。
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is commonly performed to treat a variety of benign and malignant hematological diseases. Acute graft-versus-host disease (GVHD) is a major life-threatening complication that often occurs following allo-HSCT. Recently, improvements in methods to characterize the microbiota have led to a greater appreciation for how frequently and profoundly an alteration in microbial composition, or dysbiosis, can occur in allo-HSCT recipients to better decipher the complex interplay of between microbiota and allo-HSCT outcomes. This article reviews the current knowledge of the microbiota’s impact on allo-HSCT outcomes, including effects of microbiota-derived metabolites, and crosstalk between commensals and the allogeneic immune response. This article also summarizes the effects of HSCT and transplant-related procedures on microbiota, and recent developments in interventional strategies. A growing body of literature indicate that the composition of the intestinal microbiota can function as a predictive biomarker for the risk and severity of acute GVHD, as well as overall survival, in patients undergoing allo-HSCT. Mechanisms underpinning this associations, however, are not well-understood, and clinical strategies that modulate the microbiome to improve outcomes have yet to be fully developed. There is an unmet need to determine mechanisms to improve the efficacy of allo-HSCT.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.8
作者：
Frère, P;Hermanne, JP;Beguin, Y
通讯作者：
Beguin, Y
影响因子：
5.9
作者：
D'Amico, Federica;Biagi, Elena;Candela, Marco
通讯作者：
Candela, Marco
影响因子：
20.3
作者：
Beelen, DW;Elmaagacli, A;Schaefer, UW
通讯作者：
Schaefer, UW
影响因子：
11.8
作者：
Freifeld, Alison G.;Bow, Eric J.;Wingard, John R.
通讯作者：
Wingard, John R.