Subversion of Cell Signaling by Pathogens
Subversion of Cell Signaling by Pathogens
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DOI：
10.1101/cshperspect.a006114
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发表时间：
2012-09-01
影响因子：
7.2
通讯作者：
Orth, Kim
中科院分区：
文献类型：
--
作者：
Alto, Neal M.;Orth, Kim
病原体在感染期间利用几种真核细胞信号通路。它们进化出特定的效应器和毒素来劫持宿主细胞机制以谋取自身利益。信号分子优先被病原体靶向，因为它们在全球范围内调节许多细胞过程。病毒和细菌都操纵和控制调节宿主细胞存活和形状的途径，包括MAPK信号传导、G蛋白信号传导、控制细胞骨架动力学的信号和先天免疫应答。
Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses.