Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy
Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy
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发表时间：
2008-05
期刊：
影响因子：
2.2
通讯作者：
K. Matsuyama;N. Ogata;M. Matsuoka;C. Shima;M. Wada;N. Jo;M. Matsumura
中科院分区：
文献类型：
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作者：
K. Matsuyama;N. Ogata;M. Matsuoka;C. Shima;M. Wada;N. Jo;M. Matsumura
目的糖尿病视网膜病变和糖尿病肾病是糖尿病患者中被认为具有相关性的微血管并发症。色素上皮衍生因子（PEDF）是一种强血管生成抑制剂，在糖尿病患者，特别是增生性糖尿病视网膜病变（PDR）患者的血液中显著升高。另一方面，据报道，糖尿病肾病患者血液中的PEDF水平较低。本研究的目的是确定糖尿病视网膜病变患者PEDF与肾功能之间的关系。方法对243例2型糖尿病患者进行分析。评估糖尿病视网膜病变与PEDF、HbA1c、尿素氮（BUN）、肌酐水平的关系。结果PDR患者血浆PEDF水平（7.69±6.14µg/ml，平均值±标准误差）显著高于轻至中度非增殖性糖尿病视网膜病变患者（5.07±4.37µg/ml, p=0.02）。BUN和肌酐水平随着糖尿病视网膜病变分期的进展而明显升高。血浆PEDF水平与BUN、肌酐水平显著相关（r=0.54, p<0.0001; r=0.57, p<0.0001）。结论血浆PEDF水平随着糖尿病视网膜病变和肾病的进展而升高。因此，血液中PEDF水平的升高可能表明糖尿病患者微血管损伤，并可能预测视网膜病变和肾病的进展。
Purpose Diabetic retinopathy and nephropathy are microvascular complications in patients with diabetes that are considered to be related. Pigment epithelium-derived factor (PEDF), a strong inhibitor of angiogenesis, is significantly elevated in the blood of diabetic patients, especially those with proliferative diabetic retinopathy (PDR). The level of PEDF in the blood, on the other hand, is reported to be low in a diabetic nephropathy. The aim of this study was to determine the relationship between PEDF and renal function in patients with diabetic retinopathy. Methods A total of 243 type 2 diabetic patients were studied. The relationship between the diabetic retinopathy and levels of PEDF, HbA1c, blood urea nitrogen (BUN), and creatinine were evaluated. Results The mean plasma PEDF level in patients with PDR (7.69±6.14 µg/ml; mean±standard error) was significantly higher than that of mild-to-moderate nonproliferative diabetic retinopathy (5.07±4.37 µg/ml, p=0.02). The level of BUN and creatinine increased significantly as the stage of diabetic retinopathy advanced. The plasma PEDF levels were significantly correlated with the levels of BUN and creatinine (r=0.54, p<0.0001; r=0.57, p<0.0001, respectively). Conclusions The levels of plasma PEDF increases with advances in both diabetic retinopathy and nephropathy. Thus, increased levels of PEDF in the blood may indicate microvascular damages in diabetic patients and may be predictor of the progression of retinopathy and nephropathy.