Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma
Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma
复制标题
DOI：
10.3892/ijo.2012.1702
复制
发表时间：
2013-01-01
影响因子：
5.2
通讯作者：
Andersson, Sonia
中科院分区：
文献类型：
--
作者：
Muller, Susanne;Lindquist, David;Andersson, Sonia
宫颈腺癌的发病率占所有宫颈癌的10-20%，在过去二十年中在发达国家持续增加，不像鳞状细胞宫颈癌。尽管进行了广泛的巴氏涂片细胞学检查，但仍出现了这种增长趋势，特别是在40岁以下的妇女中。因此，迫切需要对宫颈腺癌的病因学有更深入的了解，更好的预防措施和可靠的预后指标。人类富含亮氨酸重复序列和免疫球蛋白样结构域（LRIG）基因家族包括：LRIG 1、LRIG 2和LRIG 3。LRIG表达已被证明在不同类型的人类癌症中具有预后价值，包括乳腺癌、早期浸润性鳞状宫颈癌、皮肤鳞状细胞癌、少突胶质细胞瘤和星形细胞瘤。LRIG 1作为肿瘤抑制因子发挥作用，而LRIG 2和LRIG 3的功能知之甚少。本研究通过免疫组织化学方法评估了86例单纯宫颈腺癌患者肿瘤标本中三种LRIG蛋白的表达。研究了LRIG表达与已知预后因素（包括人乳头瘤病毒（HPV）状态、FIGO分期和组织学）之间可能的相关性。回顾性收集患者生存数据，并研究LRIG蛋白表达的可能预后价值。LRIG 1和LRIG 3阳性细胞的高染色强度与患者生存率显著相关，并且发现LRIG 1和LRIG 3染色强度与HPV状态之间呈正相关。因此，LRIG蛋白可能是宫颈腺癌进展的重要决定因素，其诊断和预后潜力应进一步研究。
The incidence of cervical adenocarcinoma, which accounts for 10-20% of all cervical cancers, has increased continuously in developed countries during the last two decades, unlike squamous cell cervical carcinoma. This increasing trend, noted particularly among women under the age of 40 years, has occurred despite extensive cytological Pap smear screening. A deeper understanding of the etiology of cervical adenocarcinoma, better preventive measures and reliable prognostic markers are urgently needed. The human leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family includes: LRIG1, LRIG2 and LRIG3. LRIG expression has proven to be of prognostic value in different types of human cancers, including breast cancer, early stage invasive squamous cervical cancer, cutaneous squamous cell carcinoma, oligodendroglioma and astrocytoma. LRIG1 functions as a tumor suppressor, while less is known about the functions of LRIG2 and LRIG3. This study evaluated the expression of the three LRIG proteins in tumor specimens from 86 women with pure cervical adenocarcinoma by immunohistochemistry. Possible correlations between LRIG expression and known prognostic factors, including human papillomavirus (HPV) status, FIGO stage and histology were investigated. Patient survival data were collected retrospectively and the possible prognostic value of LRIG protein expression was investigated. High staining intensity of LRIG1 and high fraction of LRIG3-positive cells were significantly associated with patient survival, and positive correlations were found between LRIG1 and LRIG3 staining intensity and HPV status. Thus, the LRIG proteins may be important determinants of cervical adenocarcinoma progression and their diagnostic and prognostic potential should be studied further.