Patterns of Systemic and Cervicovaginal Fluid Inflammatory Cytokines throughout Pregnancy
Patterns of Systemic and Cervicovaginal Fluid Inflammatory Cytokines throughout Pregnancy
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DOI：
10.1055/s-0037-1608677
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发表时间：
2018-04-01
影响因子：
2
通讯作者：
O'Brien, John
中科院分区：
文献类型：
--
作者：
Ashford, Kristin B.;Chavan, Niraj;O'Brien, John
目的本研究描述了正常孕妇血清和宫颈阴道液（CVF）中细胞因子水平的变化，研究设计本多中心前瞻性研究检测了妊娠期特异性母血和CVF细胞因子（白细胞介素[IL]-1，IL-1，IL-6，IL-8，IL-10，肿瘤坏死因子和C反应蛋白[CRP]）。一个双因素线性混合建模方法比较细胞因子分布，而成对比较评估随着时间的差异。结果妊娠期特异性血清细胞因子数据为288，243，和221例，而CVF细胞因子数据为273，229，和198例。CVF组IL-1、IL-6、IL-8和基质金属蛋白酶-8的浓度显著高于对照组（p
Objective This study describes the normal variations in serum and cervicovaginal fluid (CVF) cytokine levels throughout pregnancy.Study Design This multicenter, prospective study examined trimester-specific maternal serum and CVF cytokines (interleukin [IL]-1, IL-1, IL-6, IL-8, IL-10, tumor necrosis factor-, and C-reactive protein [CRP]). A two-factor linear mixed modeling approach compared cytokine distribution, while pairwise comparisons evaluated differences over time.Results Trimester-specific serum cytokine data were available for 288, 243, and 221 patients, whereas CVF cytokine data were available for 273, 229, and 198 patients. CVF had significantly higher concentrations of IL-1, IL-1, IL-6, IL-8, and matrix metalloproteinase-8 ( p