Epidermal Langerhans cells bear Fc and C3 receptors
Epidermal Langerhans cells bear Fc and C3 receptors
复制标题
表皮朗格汉斯细胞具有 Fc 和 C3 受体
作者：
G. Stingl;E. Wolff;W. Pichler;F. Gschnait;W. Knapp;K. Wolff
哺乳动物的表皮含有树突状细胞系统，通常被称为朗格汉斯细胞，其功能尚不清楚。然而，公认朗格汉斯细胞是间充质来源的，并且由于已知它们也存在于真皮、淋巴结、胸腺和其他器官中，朗格汉斯细胞的概念已经扩大到包括哺乳动物结缔组织和某些分层鳞状上皮细胞的细胞系统1。在关于其生物学意义的许多假设中，它们被认为代表免疫活性细胞或可能捕获抗原物质的细胞2，但对此没有足够的证据。在豚鼠对二硝基氯苯的迟发型超敏反应中观察到淋巴细胞与朗格汉斯细胞密切相关3;当豚鼠用铁蛋白超敏供体的淋巴细胞被动致敏时，用铁蛋白激发，在激发动物的引流淋巴结中观察到含铁蛋白的朗格汉斯细胞4。金属和某些胺在体外对朗格汉斯细胞具有亲和力5，但由于它们可以吞噬铁蛋白和其他物质而无需预先致敏1，因此它们是否在免疫学上参与潜在抗原物质的摄取和转运仍存在疑问。如果朗格汉斯细胞确实参与了免疫反应，那么它们应该带有一些具有已知免疫功能的细胞的表面标志物，我们现在已经证明它们携带Fc和C3受体。
THE mammalian epidermis contains a system of dendritic cells, eponymously referred to as Langerhans cells, whose functions are obscure. It is, however, accepted that Langerhans cells are of mesenchymal origin and since they are known also to occur in the dermis, lymph nodes, thymus, and other organs, the concept of Langerhans cells has widened to encompass a cellular system populating the connective tissues and certain stratified squamous epithelia of mammals1. Among the many hypotheses about their biological significance they have been considered to represent immunocompetent cells or cells which might capture antigenic materials2, but there is insufficient evidence for this. Lymphocytes have been observed to be closely associated with Langerhans cells in delayed type hypersensitivity reactions to dinitrochloro-benzene in guinea pigs3; and when guinea pigs passively sensitised with lymphocytes from ferritin-hypersensitive donors, were challenged with ferritin, ferritin-containing Langerhans cells were observed in the draining lymph nodes of the challenged animals4. Metals and certain amines have an affinity for Langerhans cells in vitro5, but since they can phagocytose ferritin and other substances without previous sensitisation1, doubt remains whether they are immunologically engaged in the uptake and transport of potentially antigenic material. If Langerhans cells are indeed involved in immunological reactions, they should bear some of the surface markers characteristics of cells with known immunological functions, and we have now shown that they carry receptors for Fc and C3.