MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord.
MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord.
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DOI：
10.1523/jneurosci.1169-10.2010
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发表时间：
2010-06-16
期刊：
影响因子：
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通讯作者：
Qiu M
中科院分区：
文献类型：
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作者：
Zheng K;Li H;Zhu Y;Zhu Q;Qiu M
在发育中的中枢神经系统(CNS)中，神经元和神经胶质细胞是由脑室神经前体细胞依次产生的。发育神经生物学中的一个基本问题是，是什么信号或因素控制着从神经发生到神经胶质发生的发育转换。在这里，我们报告miRNAs在这一重要的发育过程中发挥着至关重要的作用。抑制寡聚1Cre介导的条件基因敲除小鼠的miRNA的形成会破坏腹侧神经上皮细胞的少突胶质细胞和星形胶质细胞的形成。相比之下，突变的脊髓组织中运动神经元的早期构型和发育没有受到影响。
In the developing central nervous system (CNS), neurons and glia are sequentially produced from the ventricular neural progenitor cells. One fundamental question in developmental neurobiology is what signals or factors control the developmental switch from neurogenesis to gliogenesis. Here we report that miRNAs play an essential role in this important developmental process. Inhibition of miRNA formation in Olig1Cre – mediated Dicer conditional knockout mice disrupted both oligodendrogenesis and astrogliogenesis in the ventral neuroepithelial cells. By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue.