Longitudinal changes in the contribution of genetic and environmental influences to symptoms of depression in older male twins.
Longitudinal changes in the contribution of genetic and environmental influences to symptoms of depression in older male twins.
复制标题
遗传和环境影响对老年男性双胞胎抑郁症状的纵向变化。
DOI：
10.1037//0882-7974.15.3.505
复制
发表时间：
2000
影响因子：
3.7
通讯作者：
Miller,B
中科院分区：
文献类型：
--
作者：
Carmelli,D;Swan,GE;Kelly-Hayes,M;Wolf,PA;Reed,T;Miller,B
关于抑郁症自我报告症状的遗传信息纵向数据允许调查整个成年生活中抑郁症症状的稳定性和变化的原因。在这份报告中，作者调查了来自国家心肺血液研究所（NHLBI）双胞胎研究的83对同卵和84对异卵男性双胞胎的遗传和环境影响对抑郁症状的相对贡献。参与者首先在1985-1986年完成了流行病学抑郁症中心（CES-D）量表，并在1995-1997年再次完成。双胞胎的基线平均年龄为63岁，范围为59 - 70岁。根据横断面遗传分析，我们估计基线时CES-D的遗传率为25%（95%置信区间[CI]，11%-39%），随访时为55%（95% CI，40%-71%）。拟合纵向遗传模型的两波数据，我们发现，在10年的随访症状的稳定性主要是由于遗传影响的连续性。
Genetically informative longitudinal data on self-reported symptoms of depression allow for an investigation of the causes of stability and change in depression symptoms throughout adult life. In this report, the authors investigated the relative contribution of genetic and environmental influences to symptoms of depression in 83 monozygotic and 84 dizygotic male twin pairs from the National Heart, Lung, and Blood Institute (NHLBI) Twin Study. Participants first completed the Center for Epidemiologic Studies—Depression (CES–D) scale in 1985–1986 and again during 1995–1997. Mean age of twins at baseline was 63 years, range 59 to 70. From cross-sectional genetic analyses we estimated the heritability of CES–D to be 25%(95% confidence interval [CI], 11%–39%) at baseline and 55%(95% CI, 40%–71%) at follow-up. Fitting longitudinal genetic models to the two-wave data, we found that stability of symptoms over the 10-year follow-up was due primarily to continuity of genetic influences.