Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
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DOI：
10.1056/nejm200005183422003
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发表时间：
2000-05-18
影响因子：
158.5
通讯作者：
Salusky, IB
中科院分区：
文献类型：
--
作者：
Goodman, WG;Goldin, J;Salusky, IB
背景：心血管疾病在接受常规透析的老年终末期肾病患者中是常见的，但对儿童和青年终末期肾病患者心血管疾病的患病率和程度知之甚少。方法：我们使用电子束计算机断层扫描(CT)对39例接受透析的年轻终末期肾病患者(平均[+/-SD]年龄，19+/-7岁，范围7-30岁)和60名20-30岁的正常受试者进行冠状动脉钙化筛查。在CT扫描有钙化证据的患者中，我们确定了钙化的范围。结果：23例20岁以下患者均无冠状动脉钙化，16例20~30岁患者有14例冠状动脉钙化。在有钙化者中，平均钙化评分为1157+/-1996，中位数为297。相比之下，60名正常受试者中只有3人有钙化。与无冠状动脉钙化的患者相比，有钙化的患者年龄更大(26+/-3年比15+/-5岁，P
Background: Cardiovascular disease is common in older adults with end-stage renal disease who are undergoing regular dialysis, but little is known about the prevalence and extent of cardiovascular disease in children and young adults with end-stage renal disease.Methods: We used electron-beam computed tomography (CT) to screen for coronary-artery calcification in 39 young patients with end-stage renal disease who were undergoing dialysis (mean [+/-SD] age, 19+/-7 years; range, 7 to 30) and 60 normal subjects 20 to 30 years of age. In those with evidence of calcification on CT scanning, we determined its extent. The results were correlated with the patients' clinical characteristics, serum calcium and phosphorus concentrations, and other biochemical variables.Results: None of the 23 patients who were younger than 20 years of age had evidence of coronary-artery calcification, but it was present in 14 of the 16 patients who were 20 to 30 years old. Among those with calcification, the mean calcification score was 1157+/-1996, and the median score was 297. By contrast, only 3 of the 60 normal subjects had calcification. As compared with the patients without coronary-artery calcification, those with calcification were older (26+/-3 vs. 15+/-5 years, P