Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient.
Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient.
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DOI：
10.1128/mbio.01450-14
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发表时间：
2014-07-22
期刊：
影响因子：
6.4
通讯作者：
Madani TA
中科院分区：
文献类型：
--
作者：
Azhar EI;Hashem AM;El-Kafrawy SA;Sohrab SS;Aburizaiza AS;Farraj SA;Hassan AM;Al-Saeed MS;Jamjoom GA;Madani TA
中东呼吸综合征冠状病毒（MERS-CoV）是一种新型β冠状病毒，自2012年以来一直在阿拉伯半岛流行，并导致人类严重呼吸道感染。虽然蝙蝠被认为与人类MERS-CoV感染有关，但蝙蝠与MERS-CoV之间的直接联系尚不确定。另一方面，血清学和病毒学数据表明单峰骆驼是MERS CoV的潜在动物宿主。最近，我们从一只骆驼及其感染的主人身上分离出MERS-CoV，并为MERS-CoV从感染的骆驼直接传播给患者提供了证据。在这里，我们扩展了这项工作，并表明在我们以前的研究中从庇护受感染骆驼的同一谷仓收集的空气样本中检测到相同的MERS-CoV RNA片段。这些数据表明，该病毒在该农场中传播，同时在骆驼和患者中检测到该病毒，这需要进一步调查MERS CoV可能的空气传播。这项工作清楚地强调了持续监测和感染控制措施对控制中东呼吸综合征冠状病毒全球公共威胁的重要性。虽然目前MERS-CoV的传播似乎是有限的，但我们建议尽量减少与骆驼的接触，特别是免疫功能低下的个体，并在处理感染患者时使用适当的健康，安全和感染预防和控制措施。此外，必须考虑任何MERS-CoV病例的详细临床病史以及对任何动物暴露进行的流行病学和实验室调查，以确定任何动物来源。
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel betacoronavirus that has been circulating in the Arabian Peninsula since 2012 and causing severe respiratory infections in humans. While bats were suggested to be involved in human MERS-CoV infections, a direct link between bats and MERS-CoV is uncertain. On the other hand, serological and virological data suggest dromedary camels as the potential animal reservoirs of MERS-CoV. Recently, we isolated MERS-CoV from a camel and its infected owner and provided evidence for the direct transmission of MERS-CoV from the infected camel to the patient. Here, we extend this work and show that identical MERS-CoV RNA fragments were detected in an air sample collected from the same barn that sheltered the infected camel in our previous study. These data indicate that the virus was circulating in this farm concurrently with its detection in the camel and in the patient, which warrants further investigations for the possible airborne transmission of MERS-CoV. This work clearly highlights the importance of continuous surveillance and infection control measures to control the global public threat of MERS-CoV. While current MERS-CoV transmission appears to be limited, we advise minimal contact with camels, especially for immunocompromised individuals, and the use of appropriate health, safety, and infection prevention and control measures when dealing with infected patients. Also, detailed clinical histories of any MERS-CoV cases with epidemiological and laboratory investigations carried out for any animal exposure must be considered to identify any animal source.