Circadian variation in mouse hippocampal cell proliferation
Circadian variation in mouse hippocampal cell proliferation
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DOI：
10.1016/j.neulet.2006.07.058
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发表时间：
2006-10-09
影响因子：
2.5
通讯作者：
Jacobs, Barry L.
中科院分区：
文献类型：
--
作者：
Kochman, Linda J.;Weber, E. Todd;Jacobs, Barry L.
在12:12 h的明暗循环中，研究了成年雄性小鼠（C57BL/6J）的海马细胞增殖和伴随的运动活动。5-溴-2'-脱氧尿苷（BrdU） （200 mg/kg, i.p）在24小时内的六个等间隔时间点给予。细胞增殖在门部（光期>暗期）有显著变化，但在颗粒细胞层(GCL)/亚颗粒区（SGZ）没有变化。由于一般认为门窝和GCL/SGZ的增殖细胞分别主要产生胶质细胞和神经元，这些数据表明可能是昼夜节律影响胶质细胞的发生，而不是神经发生。2006爱思唯尔爱尔兰有限公司版权所有。
Hippocampal cell proliferation and concomitant motor activity were examined in adult male mice (C57BL/6J) across a 12:12 h light-dark cycle. 5-Bromo-2'-deoxyuridine (BrdU) (200 mg/kg, i.p.) was administered at six equally spaced time points across 24 h. A significant change in cell proliferation was found in the hilus (light phase > dark phase), but not in the granule cell layer (GCL)/subgranular zone (SGZ). Since it is generally believed that proliferating cells in the hilus and GCL/SGZ give rise primarily to glia and neurons, respectively, these data suggest a possible circadian influence on gliogenesis, rather than neurogenesis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.