HIF-1α promotes the migration and invasion of hepatocellular carcinoma cells via the IL-8-NF-κB axis.
HIF-1α promotes the migration and invasion of hepatocellular carcinoma cells via the IL-8-NF-κB axis.
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DOI：
10.1186/s11658-018-0077-1
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发表时间：
2018
影响因子：
8.3
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Feng W;Xue T;Huang S;Shi Q;Tang C;Cui G;Yang G;Gong H;Guo H
缺氧在许多癌症中起着至关重要的作用。缺氧诱导因子-1α（HIF-1α）是缺氧反应的重要介质。它调节参与肿瘤生长、血管生成和转移的各种趋化因子的表达，但相关途径需要进一步研究。测定肝细胞癌 (HCC) 细胞中 HIF-1α 的表达水平。通过敲除 HIF-1α 来评估白细胞介素 8 (IL-8) 和 HIF-1α 的相关性。这些细胞还用于评估其对 HCC 细胞迁移和侵袭的影响。吡咯烷二硫代氨基甲酸酯 (PDTC) 是一种 NF-κB 抑制剂，用于确认相关的信号通路。 HIF-1α在HCC细胞中显着表达，并被发现以IL-8依赖性方式促进HCC细胞迁移和侵袭。 NF-κB被证实参与了这一过程。 HIF-1α 通过 NF-κB 通路调节 IL-8，促进 HCC 细胞迁移和侵袭。
Hypoxia plays a critical role in many cancers. Hypoxia inducible factor-1α (HIF-1α) is an important mediator of the hypoxia response. It regulates the expression of various chemokines involved in tumor growth, angiogenesis and metastasis but the associated pathway needs further investigation. The expression level of HIF-1α was determined in hepatocellular carcinoma (HCC) cells. The correlation of interleukin-8 (IL-8) and HIF-1α was assessed by knocking down HIF-1α. These cells were also used to assess its influence on HCC cell migration and invasion was checked. Pyrrolidinedithiocarbamate (PDTC), an inhibitor of NF-κB, was used to confirm the associated signaling pathway. HIF-1α was significantly expressed in HCC cells and found to promote HCC cell migration and invasion in an IL-8-dependent manner. NF-κB was confirmed to be involved in the process. HIF-1α promotes HCC cell migration and invasion by modulating IL-8 via the NF-κB pathway.
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影响因子：
4.2
作者：
Lee, Joon Ho;Hur, Wonhee;Yoon, Seung Kew
通讯作者：
Yoon, Seung Kew
影响因子：
20.3
作者：
Hinz, M;Löser, P;Scheidereit, C
通讯作者：
Scheidereit, C
影响因子：
9
作者：
Portolani, N;Coniglio, A;Giulini, SM
通讯作者：
Giulini, SM
影响因子：
5.8
作者：
Baay-Guzman GJ;Bebenek IG;Zeidler M;Hernandez-Pando R;Vega MI;Garcia-Zepeda EA;Antonio-Andres G;Bonavida B;Riedl M;Kleerup E;Tashkin DP;Hankinson O;Huerta-Yepez S
通讯作者：
Huerta-Yepez S
影响因子：
56.9
作者：
Ivan, M;Kondo, K;Kaelin, WG
通讯作者：
Kaelin, WG