Magnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron.
Magnetic resonance assessment of iron overload by separate measurement of tissue ferritin and hemosiderin iron.
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DOI：
10.1111/j.1749-6632.2010.05587.x
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发表时间：
2010-08
影响因子：
5.2
通讯作者：
Brittenham GM
中科院分区：
文献类型：
--
作者：
Wu EX;Kim D;Tosti CL;Tang H;Jensen JH;Cheung JS;Feng L;Au WY;Ha SY;Sheth SS;Brown TR;Brittenham GM
With transfusional iron overload, almost all the excess iron is sequestered intracellularly as rapidly mobilizable, dispersed, soluble, ferritin iron, and as aggregated, insoluble hemosiderin iron for long-term storage. Established magnetic resonance imaging (MRI) indicators of tissue iron (R2, R2*) are principally influenced by hemosiderin iron and change slowly, even with intensive iron chelation. Intracellular ferritin iron is evidently in equilibrium with the low-molecular-weight cytosolic iron pool that can change rapidly with iron chelation. We have developed a new magnetic resonance imaging (MRI) method to separately measure ferritin and hemosiderin iron, based on the non-monoexponential signal decay induced by aggregated iron in multiple-spin-echo sequences. We have initially validated the method in agarose phantoms and in human liver explants and shown the feasibility of its application in patients with thalassemia major. Measurement of tissue ferritin iron is a promising new means to rapidly evaluate the effectiveness of iron-chelating regimens.
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影响因子：
3.3
作者：
Jensen, JH;Chandra, R
通讯作者：
Chandra, R
影响因子：
3.3
作者：
Gossuin, Y;Roch, A;Lo Bue, F
通讯作者：
Lo Bue, F
影响因子：
24.5
作者：
Miyazaki, E;Kato, J;Niitsu, Y
通讯作者：
Niitsu, Y
影响因子：
3
作者：
Chasteen, ND;Harrison, PM
通讯作者：
Harrison, PM
影响因子：
3.3
作者：
Ghugre, NR;Coates, TD;Wood, JC
通讯作者：
Wood, JC