Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization.
Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization.
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作者：
脑肿瘤对大脑的结构组织有深远的影响，特别是当位于语言相关区域附近时，会导致语言处理受损。为了研究这一现象，我们研究了左半球（语言优势）和右半球（语言非优势）脑肿瘤患者的高分辨率MRI扫描，并将其与对照组进行比较。具体来说，我们检查了10个语言相关区域的灰质体积。我们的研究结果表明，脑肿瘤，无论其偏侧诱导全球体积的变化，在受影响的和对侧半球。这些变化受到肿瘤偏侧化的影响，表明大脑经历了结构重塑，以科普肿瘤引起的语言缺陷。这项研究揭示了脑肿瘤和语言处理之间的复杂关系，并有助于理解病变发生后的神经可塑性机制。通过功能磁共振成像评估，左半球的脑肿瘤可以减少语言偏侧性。然而，目前还不清楚这种语言偏侧性的降低是否与灰质的结构重塑有关，特别是在语言网络中。在这里，我们检查是否破坏的语言枢纽专门影响的宏观结构特性的对侧同源物，或者它是否影响两个半球。本研究使用基于体素的形态测量法，应用于31例成人患者左半球的高分辨率MR T1加权MPH图像，该半球主要用于语言。18名患者的大脑肿瘤位于左半球，13名患者的肿瘤位于右半球。将年龄和性别匹配的71名健康个体的队列用作基线。我们定义了每个半球10个涉及语言功能的ROI。以每个区域的体积作为因变量，进行了两次单独的重复测量ANOVA。对于患者，肿瘤偏侧（右侧与左侧）作为受试者之间的因素。目前的研究表明，脑肿瘤的存在会产生影响左侧语言区域及其对侧同源物的整体体积变化。这些变化是由病变的偏侧化介导的。我们的研究结果表明，功能机制的灰质的重排支持。
Brain tumors have a profound impact on the structural organization of the brain, particularly when located near language-related regions, resulting in impaired language processing. To investigate this phenomenon, we studied high-resolution MRI scans of patients with brain tumors in the left (dominant for language) and right (nondominant for language) hemispheres and compared them to controls. Specifically, we examined the grey matter volume in 10 language-related regions. Our findings demonstrate that brain tumors, regardless of their lateralization induce global volumetric changes in both the affected and contralesional hemispheres. These changes are influenced by the tumor’s lateralization and suggest that the brain undergoes structural reshaping to cope with the language deficits caused by the tumors. This study sheds light on the intricate relationship between brain tumors and language processing and contributes to the understanding of the mechanisms underlying neuroplasticity subsequent to lesion occurrence. A brain tumor in the left hemisphere can decrease language laterality as assessed through fMRI. However, it remains unclear whether or not this decreased language laterality is associated with a structural reshaping of the grey matter, particularly within the language network. Here, we examine if the disruption of the language hubs exclusively affects the macrostructural properties of the contralateral homologues or whether it affects both hemispheres. This study uses voxel-based morphometry applied to high-resolution MR T1-weighted MPRAGE images from 31 adult patients’ left hemisphere, which is dominant for language. Eighteen patients had brain tumors in the left hemisphere, and thirteen had tumors in the right hemisphere. A cohort of 71 healthy individuals matched with respect to age and sex was used as a baseline. We defined 10 ROIs per hemisphere involved in language function. Two separate repeated-measure ANOVAs were conducted with the volume per region as the dependent variable. For the patients, tumor lateralization (right versus left) served as a between-subject factor. The current study demonstrated that the presence of a brain tumor generates global volumetric changes affecting the left language regions and their contralateral homologues. These changes are mediated by the lateralization of the lesion. Our findings suggest that functional mechanisms are supported by the rearrangement of the grey matter.
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DOI：
10.1093/brain/awx086
发表时间：
2017-06-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Hope TMH;Leff AP;Prejawa S;Bruce R;Haigh Z;Lim L;Ramsden S;Oberhuber M;Ludersdorfer P;Crinion J;Seghier ML;Price CJ
通讯作者：
Price CJ
影响因子：
11
作者：
Duffau, H;Capelle, L;Van Effenterre, R
通讯作者：
Van Effenterre, R
影响因子：
2.5
作者：
Fierstra, Jorn;van Niftrik, Christiaan;Regli, Luca
通讯作者：
Regli, Luca
影响因子：
5.3
作者：
Majewska, AK;Newton, JR;Sur, M
通讯作者：
Sur, M
影响因子：
2.6
作者：
Park, Haeme R. P.;Badzakova-Trajkov, Gjurgjica;Waldie, Karen E.
通讯作者：
Waldie, Karen E.