Prospective assessment of time-dependent changes in quality of life of Japanese patients with prostate cancer following robot-assisted radical prostatectomy
Prospective assessment of time-dependent changes in quality of life of Japanese patients with prostate cancer following robot-assisted radical prostatectomy
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DOI：
10.1007/s11701-016-0565-0
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发表时间：
2016-09-01
影响因子：
2.3
通讯作者：
Fujisawa, Masato
中科院分区：
文献类型：
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作者：
Miyake, Hideaki;Miyazaki, Akira;Fujisawa, Masato
本研究的目的是描述日本患者在机器人辅助根治性前列腺切除术（RARP）后生活质量（QOL）的变化。本研究纳入了298例连续接受RARP的局限性前列腺癌（PC）患者。分别使用医疗结局研究8项简表（SF - 8）和扩展前列腺癌指数综合评分（EPIC）在RARP术前以及术后1、3、6、12和24个月对健康相关生活质量和疾病特异性生活质量进行评估。在RARP术后1个月，SF - 8的八项评分中有四项（生理功能、因身体健康问题导致的角色受限、社会功能以及因情感问题导致的角色受限）与基线评分相比显著降低。然而，除RARP术后1个月外，所有术后评估的八项评分与基线评分均无显著差异。尽管在所有时间点，EPIC的基线评估和术后评估之间在肠道功能、肠道困扰、性困扰、激素功能或激素困扰方面均无显著差异，但RARP术后1、3和6个月的 urinary function（泌尿功能）、尿失禁和性功能评分显著低于基线评分，并且RARP术后1个月的泌尿困扰和泌尿刺激/梗阻评分与基线评分相比显著降低。这些研究结果表明，接受RARP的日本前列腺癌患者的健康相关生活质量在RARP术后可能不会明显恶化；然而，就疾病特异性生活质量而言，泌尿和性功能，尤其是RARP术后早期的泌尿和性功能，似乎受到显著损害。
The objective of this study was to characterize changes in the quality of life (QOL) of Japanese patients following robot-assisted radical prostatectomy (RARP). This study included 298 consecutive localized prostate cancer (PC) patients undergoing RARP. The health-related QOL and disease-specific QOL were assessed using The Medical Outcomes Study 8-Item Short Form (SF-8) and The Extended Prostate Cancer Index Composite (EPIC), respectively, before and 1, 3, 6, 12 and 24 months after RARP. At 1 month after RARP, four (physical function, role limitations because of physical health problems, social function and role limitations because of emotional problems) of the eight scores in SF-8 were significantly impaired compared with those of baseline scores. However, all eight scores on all postoperative assessments, except for at 1 month after RARP, showed no significant differences from baseline scores. Although there were no significant differences in the bowel function, bowel bother, sexual bother, hormonal function or hormonal bother between baseline and postoperative assessments of EPIC at all time points, the urinary function, urinary incontinence and sexual function scores at 1, 3 and 6 months after RARP were significantly inferior to those of baseline scores, and urinary bother and urinary irritation/obstruction scores at 1 month after RARP were significantly impaired compared with those of baseline scores. These findings suggest that the health-related QOL of Japanese PC patients undergoing RARP may not be markedly deteriorated following RARP; however, as for the disease-specific QOL, urinary and sexual functions, particularly those early after RARP, appeared to be significantly impaired.