Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics
Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics
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DOI：
10.1364/ao.46.000262
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发表时间：
2007-01-10
期刊：
影响因子：
1.9
通讯作者：
Karabutov, Alexander A.
中科院分区：
文献类型：
--
作者：
Khokhlova, Tatiana D.;Pelivanov, Ivan M.;Karabutov, Alexander A.
光声（OA）断层扫描的主要医学应用之一是早期乳腺癌的诊断。开发了一种数值方法来表征OA成像系统的以下参数：分辨率、可以检测到肿瘤的最大深度和图像对比度。得到了64单元聚焦阵列换能器的参数。数值模拟的结果与已知的解析解进行了比较，并进一步验证了幻影实验。获得了浸入稀释牛奶中不同深度的3mm牛肝片的OA图像。基于建模结果，提出了一种用于OA图像对比度增强的信号滤波算法。(c)2007年，美国光学学会。
One of the major medical applications of optoacoustic (OA) tomography is in the diagnostics of early-stage breast cancer. A numerical approach was developed to characterize the following parameters of an OA imaging system: resolution, maximum depth at which the tumor can be detected, and image contrast. The parameters of the 64-element focused array transducer were obtained. The results of numerical modeling were compared with known analytical solutions and further validated by phantom experiments. The OA images of a 3 mm piece of bovine liver immersed in diluted milk at various depths were obtained. Based on the results of modeling, a signal filtering algorithm for OA image contrast enhancement has been proposed. (c) 2007 Optical Society of America.