Mechanisms of tolerance to DNA lesions in mammalian cells
Mechanisms of tolerance to DNA lesions in mammalian cells
复制标题
哺乳动物细胞对 DNA 损伤的耐受机制
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
R. Schumacher
中科院分区：
文献类型：
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作者：
R. Meneghini;C. Menck;R. Schumacher
近年来，在去除DNA损伤的过程中，不同的途径参与其中，这一点已经变得很清楚。尽管修复酶对遗传完整性进行了持续的监测，但在基因组中插入病变的部分用于DNA复制或转录之前，病变往往不会被消除。事实上，一个细胞在不显著丧失其复制能力的情况下可以忍受的未切除病变的数量令人惊讶。例如，来自某些遗传性疾病着色性干皮病(XP)†的人成纤维细胞几乎无法切除嘧啶二聚体，这是由短波紫外线产生的主要dna损伤。
In recent years it has become clear that different pathways are involved in the process of removing lesions from DNA. In spite of a continuous surveillance of the genetic integrity by repair enzymes, quite often lesions are not eliminated before the portion of the genome where they have been inserted is used for DNA replication or transcription. Actually, the number of unexcised lesions a cell can tolerate without significantly losing its capacity to reproduce is surprising. As an example, human fibroblasts from certain patients with the genetic disease xeroderma pigmentosum (XP)† are virtually unable to excise pyrimidine dimers, the major DNA lesion produced by short-wavelength UV light.