Longitudinal changes in white matter microstructure after heavy cannabis use.
Longitudinal changes in white matter microstructure after heavy cannabis use.
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DOI：
10.1016/j.dcn.2015.10.004
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发表时间：
2015-12
影响因子：
4.7
通讯作者：
Luciana M
中科院分区：
文献类型：
--
作者：
Becker MP;Collins PF;Lim KO;Muetzel RL;Luciana M
相对于健康对照对年轻成年大麻使用者的纵向评估。对白质发育进行了两年的评估。用户的几个大脑区域的白质发育是不同的。更多的大麻使用与白质发育的改变有关。对大麻使用者的扩散张量成像（DTI）研究报告了大脑白质微结构的改变，主要基于横断面研究，但改变的病因仍不清楚。我们报告了对 23 名经常吸食大麻的年轻人（基线为 18-20 岁）和 23 名年龄、性别和智商匹配且药物使用史有限的未使用对照者进行基线和 2 年随访时收集的 DTI 数据的纵向体素分析结果。大麻使用开始于 17 岁之前。大麻使用者在左右上纵束的中央和顶叶区域、左额上回附近的白质、左皮质脊髓束和胼胝体膝部外侧的右前丘脑辐射中表现出分数各向异性的纵向生长减少，并且 右侧中央/后上纵束、皮质脊髓束和后扣带回径向扩散的纵向减少。大量使用大麻与 FA 纵向增长减少相关，而言语学习指标的表现也相对受损。这些发现表明，青春期和成年早期持续大量使用大麻会改变白质微结构的持续发育，导致功能障碍。
Longitudinal assessment of young adult cannabis users relative to healthy controls. White matter development was assessed over a two-year period. White matter development is distinct in several brain regions in users. More cannabis use is associated with altered white matter development. Diffusion tensor imaging (DTI) studies of cannabis users report alterations in brain white matter microstructure, primarily based on cross-sectional research, and etiology of the alterations remains unclear. We report findings from longitudinal voxelwise analyses of DTI data collected at baseline and at a 2-year follow-up on 23 young adult (18–20 years old at baseline) regular cannabis users and 23 age-, sex-, and IQ-matched non-using controls with limited substance use histories. Onset of cannabis use was prior to age 17. Cannabis users displayed reduced longitudinal growth in fractional anisotropy in the central and parietal regions of the right and left superior longitudinal fasciculus, in white matter adjacent to the left superior frontal gyrus, in the left corticospinal tract, and in the right anterior thalamic radiation lateral to the genu of the corpus callosum, along with less longitudinal reduction of radial diffusion in the right central/posterior superior longitudinal fasciculus, corticospinal tract, and posterior cingulum. Greater amounts of cannabis use were correlated with reduced longitudinal growth in FA as was relatively impaired performance on a measure of verbal learning. These findings suggest that continued heavy cannabis use during adolescence and young adulthood alters ongoing development of white matter microstructure, contributing to functional impairment.