Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging.

Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging.
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DOI:
10.1364/oe.16.010214
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发表时间:
2008-07-07
期刊:
影响因子:
3.8
通讯作者:
Duong TQ
Duong TQ
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Cheng H;Yan Y;Duong TQ

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激光散斑图像的时间 - 统计分析(TS - LSI)与传统的空间 - 统计分析(SS - LSI)相比,保留了原始的空间分辨率。人们对TS - LSI信号的时间独立性及其对静态散斑污染的不敏感性提出了担忧。我们在流动模型和活体大鼠视网膜上的研究结果表明,TS - LSI信号在时间上具有统计独立性,并且TS - LSI可将静态散斑污染降至最低。后者是因为静态散斑是“非随机的”,因此是非各态历经的,即静态散斑的时间平均值不一定等于其空间总体平均值。TS - LSI能够检测较小血管中的血流,并且不易受到静态散斑伪影的影响。
Temporal-statistical analysis of laser-speckle image (TS-LSI) preserves the original spatial resolution, in contrast to conventional spatial-statistical analysis (SS-LSI). Concerns have been raised regarding the temporal independency of TS-LSI signals and its insensitivity toward stationary-speckle contamination. Our results from flow phantoms and in vivo rat retinas demonstrated that the TS-LSI signals are temporally statistically independent and TS-LSI minimizes stationary-speckle contamination. The latter is because the stationary speckle is “non-random” and thus non-ergodic where the temporal average of stationary speckle needs not equal its spatial ensemble average. TS-LSI detects blood flow in smaller blood vessels and is less susceptible to stationary-speckle artifacts.
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