Induction of Rejection After Small-for-Size Liver Transplantation: Size Matters
Induction of Rejection After Small-for-Size Liver Transplantation: Size Matters
复制标题
小尺寸肝移植后诱导排斥反应：尺寸很重要
DOI：
10.1080/08941930802216823
复制
发表时间：
2008
影响因子：
1.9
通讯作者：
U. Dahmen
中科院分区：
文献类型：
--
作者：
O. Dirsch;Jun Li;Qing He;Yuan Ji;Yanli Gu;U. Dahmen
背景：减体积肝移植与肝脏再生相关。本研究旨在分析移植肝大小对肝移植排斥反应和肝再生的影响。方法：采用ACI-刘易斯排斥株和BN-刘易斯接受株联合进行减体积肝移植。BN至刘易斯对照组用免疫抑制剂FK 506治疗。结果：ACI与刘易斯株联合应用可加速小体积部分肝移植的排斥反应。移植肝重量与受体肝重量的比值（GW/RLW）与存活时间呈正相关。在BN与刘易斯品系的组合中，在小体积部分肝移植物中观察到致死性排斥反应。计算出临界免疫GW/RLW为33%。在致死性排斥反应中，GW/RLW与存活时间呈正相关。GW/RLW与肝细胞增殖呈负相关。在再生肝脏中，在对照组中也观察到MHC II上调。所有对照组动物均在小体积肝移植中存活。结论：移植肝的相对大小是影响排斥反应动力学和排斥反应发生的决定性因素。相对临界免疫肝质量被确定为33%。
Background: Reduced-size liver transplantation is associated with liver regeneration. This study was designed to analyze the influence of graft size on liver rejection and liver regeneration. Methods: Reduced-size liver transplantations were performed in the rejecting ACI to Lewis and the graft acceptance BN to Lewis strain combination. The BN to Lewis control group was treated with the immunosuppressive drug FK506. Results: An accelerated liver rejection in the ACI to Lewis strain combination was found in small-for-size partial liver grafts. Graft weight to recipient liver weight ratio (GW/RLW) showed a positive correlation with survival time. In the BN to Lewis strain combination, lethal rejection was seen in small-for-size partial liver grafts. A critical immunologic GW/RLW of 33% was calculated. In rats dying from lethal rejection, GW/RLW and survival time showed a positive correlation. However, GW/RLW showed a negative correlation with hepatocellular proliferation. In regenerating livers, MHC II upregulation was also observed in the control group. All control animals survived small-for-size liver transplantation. Conclusions: The relative graft size seems to be a decisive factor influencing the kinetic of liver rejection and the induction of liver rejection. Relative critical immunologic liver mass was determined to be 33%.