Relationship between plasma renin, renin-substrate, angiotensin II, aldosterone and electrolytes in normal pregnancy.
Relationship between plasma renin, renin-substrate, angiotensin II, aldosterone and electrolytes in normal pregnancy.
复制标题
正常妊娠血浆肾素、肾素底物、血管紧张素II、醛固酮和电解质之间的关系。
DOI：
10.1210/jcem-40-1-108
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
M. Tree
中科院分区：
文献类型：
--
作者：
R. Weir;J. J. Brown;R. Fraser;A. Lever;R. W. Logan;G. McIlwaine;J. Morton;J. Robertson;M. Tree
测定正常孕妇在妊娠和产后各阶段肾素、肾素底物、血管紧张素II和醛固酮的血药浓度。肾素底物、血管紧张素II和醛固酮的平均循环水平在妊娠早期至晚期显著升高。平均血浆肾素浓度在妊娠早期最高，在妊娠晚期显著下降，但在整个妊娠期间仍高于正常的非妊娠范围。与人类许多其他生理和病理情况不同，在肾素和血管紧张素II、肾素和醛固酮或血管紧张素II和醛固酮的同时血浆浓度之间没有发现显著的关系。血浆肾素底物浓度与血浆血管紧张素II浓度无相关性，但与血浆醛固酮浓度呈正相关。血浆醛固酮浓度与血浆钠浓度呈正相关，血浆钠浓度低于血浆钠浓度。
Plasma concentrations of renin, reninsubstrate, angiotensin II and aldosterone were measured in normal pregnant women at various stages of gestation and postpartum. The mean circulating levels of renin-substrate, angiotensin II and aldosterone increased significantly from the first to the third trimester. Mean plasma renin concentration was highest in the first trimester and fell significantly to the third trimester, although it remained above the normal nonpregnant range throughout pregnancy. Unlike many other physiological and pathological situations in man, no significant relationship was found between concurrent plasma concentrations of renin and angiotensin II, renin and aldosterone or angiotensin II and aldosterone. Plasma renin-substrate concentration did not correlate with plasma angiotensin II concentration, but it did have a positive correlation with plasma aldosterone concentration. The plasma concentration of aldosterone was positively related to plasma sodium concentration, which was below th...