Effects of intra- and interindividual variation on the appropriate use of normal ranges.
Effects of intra- and interindividual variation on the appropriate use of normal ranges.
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DOI：
10.1093/clinchem/20.12.1535
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发表时间：
1974-12
影响因子：
9.3
通讯作者：
E. K. Harris
中科院分区：
文献类型：
--
作者：
E. K. Harris
基于大量个体的单个样本分布的正态范围反映了个体内和个体间的变化。如果这两种变异源的平均比例很小，那么，假设高斯分布，常规的正态范围通常会包含比预期更大的个体值分布比例。当平均比率超过1.4时，正常范围将包括比预期更大或更小的比例，这取决于个体变异是否小于或大于平均个体内变异。在某些计算可行的情况下，对多元正态区域的研究也产生了类似的结果。有了这些数值指导，来自最近血液化学研究的数据表明，传统的正常范围可能对个体生化状态的显著变化不那么敏感。这种分析支持持续开发和使用累积（及时）系统来报告个人的实验室测试结果。
Normal ranges based on the distribution of single samples from a large number of individuals reflect both intra- and interindividual variation. If the average ratio of these two sources of variation is small, then, assuming gaussian distributions, the conventional normal range will usually include a larger than expected proportion of an individual9s distribution of values. When the average ratio exceeds 1.4, the normal range will include a proportion either larger or smaller than expected, depending on whether the individual9s variability is less than or greater than average intra-individual variation. Investigation of multivariate normal regions in certain cases where calculations are feasible produced similar results. With these numerical guidelines, data from recent blood-chemistry studies indicate that conventional normal ranges are likely to be less sensitive than desired to significant changes in an individual9s biochemical state. This analysis supports the continued development and use of cumulative (in time) systems for reporting laboratory test results for individuals.