Peri-ictal ECG changes in childhood epilepsy: Implications for detection systems
Peri-ictal ECG changes in childhood epilepsy: Implications for detection systems
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DOI：
10.1016/j.yebeh.2013.06.030
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发表时间：
2013-10-01
影响因子：
2.6
通讯作者：
Lagae, Lieven
中科院分区：
文献类型：
--
作者：
Jansen, Katrien;Varon, Carolina;Lagae, Lieven
早期发现癫痫发作可以降低相关的发病率和死亡率，改善癫痫患者的生活质量。在这项研究中，目的是调查在儿童局灶性和全身性癫痫发作中是否存在发作性心动过速。对80例癫痫发作患者在癫痫发作前后的心电节段进行了时频域分析。对这些心电参数进行分析，找出可用于癫痫检测的最具信息量的参数。Leutmezer等人的算法。[17]在时间域上，局灶性发作发作前后的平均RR有显著差异。这可以在颞叶癫痫和额叶癫痫中观察到。计算平均RR间期对检测发作期心率变化有很高的特异性。发作前心率变化在70%的部分癫痫发作中观察到。在这项儿童癫痫研究中，发作前心率变化仅出现在部分癫痫发作中。这种变化可以在颞叶癫痫和额叶癫痫中观察到。在70%的局灶性癫痫发作之前，心率变化使癫痫发作检测和闭环系统成为难治性癫痫儿童人群中一种可能的治疗选择。(C)2013 Elsevier Inc.保留所有权利。
Early detection of seizures could reduce associated morbidity and mortality and improve the quality of life of patients with epilepsy. In this study, the aim was to investigate whether ictal tachycardia is present in focal and generalized epileptic seizures in children. We sought to predict in which type of seizures tachycardia can be identified before actual seizure onset.Electrocardiogram segments in 80 seizures were analyzed in time and frequency domains before and after the onset of epileptic seizures on EEG. These ECG parameters were analyzed to find the most informative ones that can be used for seizure detection. The algorithm of Leutmezer et al. [17] was used to find the temporal relationship between the change in heart rate and seizure onset.In the time domain, the mean RR shows a significant difference before compared to after onset of the seizure in focal seizures. This can be observed in temporal lobe seizures as well as frontal lobe seizures. Calculation of mean RR interval has a high specificity for detection of ictal heart rate changes.Preictal heart rate changes are observed in 70% of the partial seizures.Ictal heart rate changes are present only in partial seizures in this childhood epilepsy study. The changes can be observed in temporal lobe seizures as well as in frontal lobe seizures. Heart rate changes precede seizure onset in 70% of the focal seizures, making seizure detection and closed-loop systems a possible therapeutic alternative in the population of children with refractory epilepsy. (C) 2013 Elsevier Inc. All rights reserved.