Short Sleep Duration, Glucose Dysregulation and Hormonal Regulation of Appetite in Men and Women
Short Sleep Duration, Glucose Dysregulation and Hormonal Regulation of Appetite in Men and Women
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DOI：
10.5665/sleep.2198
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发表时间：
2012-11-01
期刊：
影响因子：
5.6
通讯作者：
Laferrere, Blandine
中科院分区：
文献类型：
--
作者：
St-Onge, Marie-Pierre;O'Keeffe, Majella;Laferrere, Blandine
研究目的：研究控制喂养条件下减少睡眠时间对激素的影响。设计：随机交叉研究。背景:住院。参与者：27名体重正常，30- 45岁的男性和女性，习惯每晚睡眠7-9小时。干预：参与者在两种睡眠条件下进行研究：短睡眠（卧床4小时）或习惯性睡眠（卧床9小时）。在每4天的研究期间提供控制饮食。测量和结果：每天采集空腹血样，并在第4天频繁采集血样。主要结局指标包括葡萄糖、胰岛素、瘦素、饥饿素、脂联素、总胰高血糖素样肽1 （GLP-1）和肽YY3-36 （PYY3-36）浓度。在习惯睡眠和短睡眠阶段，体重分别减少2.2 +/- 0.4 lb和1.7 +/- 0.4 lb （P均< 0.0001）。睡眠时间对血糖、胰岛素和瘦素没有影响（P < 0.05）。Ghrelin和GLP-1的反应因性别而异。短时间睡眠增加了男性空腹（P = 0.054）和早晨（08:00-12:00）总胃饥饿素（P = 0.042），而女性没有。而GLP-1的水平则相反：在女性中，短时间睡眠后下午（12:30-19:00）的GLP-1水平比习惯睡眠的低（P = 0.016），而在男性中则不然。结论：这些数据表明，在负能量平衡的情况下，短睡眠不会导致胰岛素抵抗增加，但可能通过不同的机制使男性和女性容易暴饮暴食。
Study Objective: To determine the hormonal effects of reducing sleep duration under controlled feeding conditions.Design: Randomized, crossover study.Setting: Inpatient.Participants: Twenty-seven normal weight, 30- to 45-yr-old men and women habitually sleeping 7-9 hr/night.Intervention: Participants were studied under two sleep conditions: short (4 hr in bed) or habitual (9 hr in bed) sleep. A controlled diet was provided for each 4-day study period.Measurements and Results: Fasting blood samples were obtained daily and frequent blood samples were obtained throughout day 4. The main outcomes measures included glucose, insulin, leptin, ghrelin, adiponectin, total glucagon-like peptide 1 (GLP-1) and peptide YY3-36 (PYY3-36) concentrations. Body weights were reduced by 2.2 +/- 0.4 lb and 1.7 +/- 0.4 lb during the habitual and short sleep phases, respectively (both P < 0.0001). There was no effect of sleep duration on glucose, insulin, and leptin profiles (all P > 0.05). Ghrelin and GLP-1 responses differed by sex. Short sleep increased fasting (P = 0.054) and morning (08:00-12:00) (P = 0.042) total ghrelin in men but not women. The reverse was observed for GLP-1: afternoon levels (12:30-19:00) were lower (P = 0.016) after short sleep compared with habitual sleep in women but not men.Conclusions: These data suggest that, in the context of negative energy balance, short sleep does not lead to a state of increased insulin resistance, but may predispose to overeating via separate mechanisms in men and women.