Non-esterified fatty acid levels and physical inactivity: the relative importance of low habitual energy expenditure and cardio-respiratory fitness
Non-esterified fatty acid levels and physical inactivity: the relative importance of low habitual energy expenditure and cardio-respiratory fitness
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DOI：
10.1079/bjn2002663
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发表时间：
2002-09-01
影响因子：
3.6
通讯作者：
Wareham, NJ
中科院分区：
文献类型：
--
作者：
Franks, PW;Wong, MY;Wareham, NJ
非酯化脂肪酸 (NEFA) 的空腹浓度及其在口服葡萄糖耐量试验中下降的程度与胰岛素抵抗和葡萄糖耐受不良密切相关。然而，相对较少的研究描述了 NEFA 浓度可能的环境决定因素。体力活动可能与 NEFA 水平有关，但习惯性活动水平在流行病学研究中很难量化。特别是，目前尚不清楚 NEFA 是否与心肺健康或习惯性能量消耗更密切相关。为了量化这些关系，我们分析了伊利前瞻性人群研究的数据，其中 931 名受试者接受了葡萄糖耐量测试，通过心率监测测量心肺健康和 4 天能量消耗，这项技术之前针对全身热量测定和双标记水进行了验证。为了估计日常健康和能量消耗的潜在变量，190 名受试者在一年内另外进行了 3 次重复测试。在仅调整年龄和性别的分析中，能量消耗和心肺健康均与口服葡萄糖负荷后的 NEFA 曲线下总面积呈负相关（标准化 beta 系数分别为 -0.030 和 -0.039；均 P
The fasting concentration of non-esterified fatty acids (NEFA) and the degree to which it declines during an oral glucose tolerance test are closely associated with insulin resistance and glucose intolerance. However, relatively few studies have described possible environmental determinants of NEFA concentrations. Physical activity is likely to be related to NEFA levels, but habitual activity level is difficult to quantify in epidemiological studies. In particular, it is unclear whether NEFA is more closely related to cardio-respiratory fitness or to habitual energy expenditure. In order to quantify these relationships, we analysed data from the Ely prospective population-based study in which 931 subjects underwent a glucose tolerance test with measurements of cardio-respiratory fitness and 4 d energy expenditure by heart-rate monitoring, a technique previously validated against whole-body calorimetry and doubly-labelled water. In order to estimate the latent variables of usual fitness and energy expenditure, a subset of 190 subjects underwent repeat testing on three further occasions over 1 year. In analyses adjusting only for age and sex, energy expenditure and cardio-respiratory fitness were both negatively correlated with the total area under the NEFA curve following the oral glucose load (standardised beta coefficients -0.030 and -0.039 respectively; both P