Error-related brain activity: A time-domain and time-frequency investigation in pediatric obsessive-compulsive disorder.
Error-related brain activity: A time-domain and time-frequency investigation in pediatric obsessive-compulsive disorder.
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DOI：
10.1111/psyp.14216
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发表时间：
2022-11
期刊：
影响因子：
3.7
通讯作者：
C. Dell’Acqua;G. Hajcak;N. Amir;N. Santopetro;C. J. Brush;A. Meyer
中科院分区：
文献类型：
--
作者：
C. Dell’Acqua;G. Hajcak;N. Amir;N. Santopetro;C. J. Brush;A. Meyer
错误相关负性增加（ERN）是一种错误监测的指标，已被认为是强迫症（OCD）的生物标志物。使用脑电图（EEG）数据的时间-频率分解可以对错误监控进行额外的了解，因为它可以解开大脑对信息的并行处理。更大的错误相关θ被认为反映了错误检测信号，而δ活动可以反映更精细的检测后过程（即，战略调整）。最近的研究表明，减少错误相关的α可能是错误后的注意力投入的指标;此外，增加和减少错误相关的β可能分别反映运动抑制和运动准备。然而，在OCD的错误监测的时间-频率动态在很大程度上是未知的。本研究采用数据驱动、基于聚类的方法研究了早期青少年强迫症患者的时频θ、δ、α和β功率。目的是探索错误监测早期青少年（n = 27，15名女性）和无强迫症（n = 27，14名女性）在箭头版本的侧翼任务，而脑电图活动记录的皮层电措施。结果表明，强迫症组的特征是ERN和错误相关θ增加，以及错误相关β功率降低减少（即，与没有强迫症的参与者相比，更大的力量。更大的错误相关β解释了强迫症的方差超过ERN和错误相关θ。通过检查单独的时间-频率测量，本研究提供了对错误监测动态的新见解，表明儿科OCD的特征可能是增强的错误监测（即，更大的θ功率）和错误后抑制（即，降低的β功率降低）。
Increased error-related negativity (ERN), a measure of error monitoring, has been suggested as a biomarker of obsessive-compulsive disorder (OCD). Additional insight into error monitoring is possible using time-frequency decomposition of electroencephalographic (EEG) data, as it allows disentangling the brain's parallel processing of information. Greater error-related theta is thought to reflect an error detection signal, while delta activity may reflect more elaborative post-detection processes (i.e., strategic adjustments). Recent investigations show that decreased error-related alpha may index attentional engagement following errors; additionally, increases and decreases in error-related beta could reflect motor inhibition and motor preparation, respectively. However, time-frequency dynamics of error monitoring in OCD are largely unknown. The present study examined time-frequency theta, delta, alpha and beta power in early adolescents with OCD using a data-driven, cluster-based approach. The aim was to explore electrocortical measures of error monitoring in early adolescents with (n = 27, 15 females) and without OCD (n = 27, 14 females) during an arrowhead version of the flanker task while EEG activity was recorded. Results indicated that the OCD group was characterized by increased ERN and error-related theta, as well as reduced error-related beta power decrease (i.e., greater power) compared to participants without OCD. Greater error-related beta explained variance in OCD over and above the ERN and error-related theta. By examining separate time-frequency measures, the present study provides novel insights into the dynamics of error monitoring, suggesting that pediatric OCD may be characterized by enhanced error monitoring (i.e., greater theta power) and post-error inhibition (i.e., reduced beta power decrease).