Slow-wave sleep and the risk of type 2 diabetes in humans
Slow-wave sleep and the risk of type 2 diabetes in humans
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DOI：
10.1073/pnas.0706446105
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发表时间：
2008-01-22
影响因子：
11.1
通讯作者：
Van Cauter, Eve
中科院分区：
文献类型：
--
作者：
Tasali, Esra;Leproul, Rachel;Van Cauter, Eve
有令人信服的证据表明，在人类中，离散的睡眠阶段对白天的大脑功能很重要，但是否有任何特定的睡眠阶段对身体的其他部分有功能意义尚不清楚。深度非快速眼动（NREM）睡眠，也被称为慢波睡眠（SWS），被认为是最具“恢复性”的睡眠阶段，但SWS对身体健康的有益影响尚未得到证实。SWS的开始与影响葡萄糖调节的激素变化相一致，表明SWS可能对正常的葡萄糖耐量很重要。如果是这样，选择性抑制SWS应该会对葡萄糖稳态产生不利影响，并增加2型糖尿病的风险。本研究表明，在年轻健康成人中，在不改变总睡眠时间的情况下，整夜选择性抑制SWS会导致胰岛素敏感性显著降低，而胰岛素释放却没有充分的代偿性增加，从而导致葡萄糖耐量降低和糖尿病风险增加。SWS抑制降低了SWS中占主导地位的脑电信号频谱范围δ谱功率，而其他脑电信号频段保持不变。重要的是，胰岛素敏感性降低的幅度与SWS降低的幅度密切相关。这些发现证明了SWS在维持正常葡萄糖稳态中的明确作用。此外，我们的数据表明，低水平的SWS会导致睡眠质量下降，这在老年人和许多肥胖者身上都有发生，可能会增加患2型糖尿病的风险。
There is convincing evidence that, in humans, discrete sleep stages are important for daytime brain function, but whether any particular sleep stage has functional significance for the rest of the body is not known. Deep non-rapid eye movement (NREM) sleep, also known as slow-wave sleep (SWS), is thought to be the most "restorative" sleep stage, but beneficial effects of SWS for physical well being have not been demonstrated. The initiation of SWS coincides with hormonal changes that affect glucose regulation, suggesting that SWS may be important for normal glucose tolerance. If this were so, selective suppression of SWS should adversely affect glucose homeostasis and increase the risk of type 2 diabetes. Here we show that, in young healthy adults, all-night selective suppression of SWS, without any change in total sleep time, results in marked decreases in insulin sensitivity without adequate compensatory increase in insulin release, leading to reduced glucose tolerance and increased diabetes risk. SWS suppression reduced delta spectral power, the dominant EEG frequency range in SWS, and left other EEG frequency bands unchanged. Importantly, the magnitude of the decrease in insulin sensitivity was strongly correlated with the magnitude of the reduction in SWS. These findings demonstrate a clear role for SWS in the maintenance of normal glucose homeostasis. Furthermore, our data suggest that reduced sleep quality with low levels of SWS, as occurs in aging and in many obese individuals, may contribute to increase the risk of type 2 diabetes.