HUMAN-FETAL LUNG-CHANGES ASSOCIATED WITH MATERNAL SMOKING DURING PREGNANCY
HUMAN-FETAL LUNG-CHANGES ASSOCIATED WITH MATERNAL SMOKING DURING PREGNANCY
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DOI：
10.1002/ppul.1950030113
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发表时间：
1987-01-01
影响因子：
3.1
通讯作者：
WANG, NS
中科院分区：
文献类型：
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作者：
CHEN, MF;KIMIZUKA, G;WANG, NS
流行病学研究充分证明了吸烟母亲的后代会出现肺损伤。功能损害的形态学基础在很大程度上是未探索的。我们研究了17个婴儿肺尸检，10个吸烟（第1组）和7个非吸烟（第2组）的母亲，光（LM），透射（TEM）和扫描电子显微镜（SEM）。通过LM，肺泡平均线性截距在两组中相似;在所有研究的肺中，总肺体积和肺泡表面积随着胎龄的增加而增加。扫描电镜观察，第1组神经上皮小体（NEB）较第2组大。扫描电镜和透射电镜观察，吸烟组NEB纤毛细胞增多，致密核心颗粒减少。母亲在怀孕期间吸烟似乎会改变胎儿NEB的大小和细胞组成。NEB改变的详细机制及其意义在本研究中尚不清楚，需要进一步澄清。Pediatr Pulmonol 1987; 3：51-85。
Pulmonary impairment in the offspring of smoking mothers is well documented by epidemiologic studies. The morphologic bases for the functional impairment are largely unexplored. We studied 17 infant lungs obtained at autopsy, ten from smoking (group 1) and seven from nonsmoking (group 2) mothers, by light (LM), transmission (TEM), and scanning electron microscopy (SEM). By LM, the alveolar mean linear intercept was similar in both groups; the total lung volume and alveolar surface area increased with the increase in gestational age in all lungs studied. By SEM, the sizes of the neuroepithelial bodies (NEB) were larger in group 1 than in group 2. By SEM and TEM, ciliated cells were increased, but the amount of dense core granules was decreased, in the NEB of the smoking group. Maternal smoking during pregnancy appears to alter the size and cellular composition of fetal NEB. The detailed mechanisms of the alteration in NEB and their implications are unclear from this study and need further clarification.Pediatr Pulmonol 1987; 3:51–85.