Factors linked to bacterial vaginosis in nonpregnant women
Factors linked to bacterial vaginosis in nonpregnant women
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DOI：
10.2105/ajph.91.10.1664
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发表时间：
2001-10-01
影响因子：
12.7
通讯作者：
Wang, J
中科院分区：
文献类型：
--
作者：
Holzman, C;Leventhal, JM;Wang, J
目标.本研究的目的是检验阴道冲洗与有症状和无症状妇女的细菌性阴道病相关的假设，并确定与细菌性阴道病相关的其他人口统计学、生殖和生活方式因素。在这项涉及3个诊所的横断面研究中，496名非妊娠女性完成了自填问卷。对他们的阴道涂片进行评估并交叉验证细菌性阴道病。各诊所细菌性阴道病的患病率范围为15%至30%。在仅限于研究中心1的分析中，细菌性阴道病的校正比值比（OR）在受教育年限为13年或更少的非裔美国妇女中仍然显著（OR = 5.5，95%置信区间[CI] = 2.1，14.5），过去6个月内使用激素（OR = 0.5，95%CI = 0.2，0.8），过去2个月内阴道冲洗（OR = 2.9，95%CI = 1.5，5.6）。两种生活方式因素与细菌性阴道病密切相关：全身避孕似乎具有保护作用，而冲洗与患病率增加有关。冲洗和细菌性阴道病之间的时间关系需要进一步澄清。
Objectives. The purposes of this study were to test the hypothesis that vaginal douching is linked to bacterial vaginosis in both symptomatic and asymptomatic women and to identify other demographic, reproductive, and lifestyle factors associated with bacterial vaginosis.Methods. In this cross-sectional study involving 3 clinic sites, 496 nonpregnant women completed a self-administered questionnaire. Their vaginal smears were assessed and cross-validated for bacterial vaginosis.Results. The prevalence of bacterial vaginosis across clinics ranged from 15% to 30%. In analyses restricted to site 1, adjusted odds ratios (ORs) for bacterial vaginosis remained significant for African American women with 13 or fewer years of education (OR = 5.5, 95% confidence interval [CI] = 2.1, 14.5), hormone use within the past 6 months (OR = 0.5, 95% Cl = 0.2,0.8), and vaginal douching within the past 2 months (OR = 2.9, 95% Cl = 1.5, 5.6).Conclusions. Two lifestyle factors emerge as strongly associated with bacterial vaginosis: systemic contraceptives appear protective, whereas douching is linked to an increase in prevalence. The temporal relationship between douching and bacterial vaginosis needs further clarification.