Influence of Nitrous Oxide on Motor-Evoked Potentials
Influence of Nitrous Oxide on Motor-Evoked Potentials
复制标题
一氧化二氮对运动诱发电位的影响
DOI：
10.1097/00007632-199705010-00012
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发表时间：
1997
期刊：
影响因子：
3
通讯作者：
J. Nadstawek
中科院分区：
文献类型：
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作者：
J. Zentner;Christoph Thees;U. Pechstein;K. Scheufler;Jens Würker;J. Nadstawek
研究设计。以兔为实验模型，进行运动诱发电位的研究。目标。目的：评价一氧化二氮对运动诱发电位的影响，同时监测肌肉和脊髓的直接反应。背景数据摘要。运动诱发电位监测为术中评估下行通路功能提供了一种有前景的工具。然而，到目前为止，这项技术仍处于实验阶段，其常规使用主要是由于麻醉的影响导致术中记录困难而受到限制。方法：研究方法。研究对象为8只体重在3000~3500g之间的公兔。在基础状态和增加一氧化二氮浓度(10-70%)的情况下，从肢体肌肉和胸髓硬膜外间隙记录到运动诱发电位。结果。作者发现，高浓度的一氧化二氮对肌电反应有主要的抑制作用。使用50%一氧化二氮时，肌电波幅被抑制到基础值的46%(前腿)和14%(后腿)，而潜伏期没有明显变化。与肌肉活动相反，代表神经活动的脊髓诱发反应不受任何浓度的一氧化二氮影响。结论。以一氧化二氮为基础的麻醉术中通过运动诱发电位监测下行通路是可行的，当评估神经活动时。然而，较高剂量的一氧化二氮与肌肉活动的记录不兼容。
Study Design. Rabbits were used as an experimental model in the study of motor-evoked potentials. Objectives. To evaluate the effect of nitrous oxide on motor-evoked potentials while monitoring direct muscle and spinal cord responses. Summary of Background Data. Motor-evoked potential monitoring provides a promising tool for intraoperative assessment of descending pathways function. However, to date, this technique is still at an experimental stage, since its routine use is mainly limited because of intraoperative recording difficulties caused by the influence of anesthesia. Methods. Eight male rabbits weighing between 3000 g and 3500 g were studied. Motor-evoked potentials were recorded from the extremity muscles and from the epidural space of the thoracic cord in response to electrical stimulation of the motor cortex at baseline conditions and at increasing nitrous oxide concentrations (10-70 vol%). Results. The authors found a major suppressive effect of high nitrous oxide concentrations on the electromyographic responses. With 50 vol% nitrous oxide, electromyographic amplitudes were suppressed to 46% (fore leg) and 14% (hind leg) of the baseline values, whereas latencies did not change significantly. In contrast to muscular activity, spinal evoked responses representing neural activity were not affected by any concentration of nitrous oxide. Conclusions. Intraoperative monitoring of descending pathways by means of motor-evoked potentials during anesthesia of the rabbits based on nitrous oxide is feasible when neural activity is evaluated. Higher doses of nitrous oxide, however, are not compatible with recording of muscular activity.
DOI：
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发表时间：
2007
期刊：
影响因子：
--
作者：
Yamamoto T;Kobayashi K;Oshima H;Fukaya C;Katayama Y
通讯作者：
Katayama Y