Predictive value of asymmetric dimethylarginine and C-reactive protein for the risk of developing metabolic syndrome in middle-aged men
Predictive value of asymmetric dimethylarginine and C-reactive protein for the risk of developing metabolic syndrome in middle-aged men
复制标题
不对称二甲基精氨酸和C反应蛋白对中年男性代谢综合征风险的预测价值
DOI：
10.1016/j.ijcme.2014.10.001
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kawada T
中科院分区：
文献类型：
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作者：
Otsuka T;Nishiyama Y;Kachi Y;Kato K;Inagaki H;Kawada T
背景我们旨在检查不对称二甲基精氨酸（ADMA）（一种一氧化氮合酶的内源性抑制剂）和C反应蛋白（CRP）的血清水平是否与中年男性患代谢综合征的风险相关。方法在这项纵向研究中，测量了没有代谢综合征的日本男性的血清ADMA和CRP水平，这些男性根据目前公认的诊断标准进行诊断。 统一标准。对受试者进行最长四年的随访以确定新发代谢综合征。应用 Cox 比例风险模型调整潜在混杂因素，根据 ADMA 和 CRP 的血清水平（单独或组合考虑）确定发生代谢综合征的风险比 (HR)。 结果 在 848 名受试者（平均年龄，43 ± 6 岁）中，100 名受试者出现代谢综合征。单独高 ADMA 水平（≥ 0.45 μmol/L）并未显示出代谢综合征发生的显着 HR，而高 CRP 水平（≥ 0.3 mg/L）却显示出显着的 HR（HR 1.75，95% CI 1.12-2.74）。与低水平的两种标志物相比，高水平的 CRP 和 ADMA 组合具有较高的 HR（2.09，95% CI 1.12-3.76）。相比之下，高CRP和低ADMA水平以及低CRP和高ADMA水平的组合的HR并不显着。结论血清CRP水平与代谢综合征的风险相关，但ADMA水平不相关。然而，通过同时考虑这两个标志物而不是单独考虑 CRP，可以更可靠地预测代谢综合征的风险。
BackgroundWe aimed to examine whether serum levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, and C-reactive protein (CRP) are associated with the risk of developing metabolic syndrome in middle-aged men.MethodsIn this longitudinal study, serum ADMA and CRP levels were measured in Japanese men without metabolic syndrome, which was diagnosed according to the currently accepted unified criteria. The subjects were followed-up for a maximum of four years to determine new-onset metabolic syndrome. A Cox proportional hazards model with adjusting for potential confounders was applied to determine the hazard ratio (HR) for developing metabolic syndrome according to serum levels of ADMA and CRP, considered either alone or in combination.ResultsOf the 848 subjects (mean age, 43 ± 6 years), 100 subjects developed metabolic syndrome. High ADMA levels (≥ 0.45 μmol/L) alone did not show a significant HR for developing metabolic syndrome, while high CRP levels (≥ 0.3 mg/L) did (HR 1.75, 95% CI 1.12–2.74). The combination of high levels of both CRP and ADMA had a high HR (2.09, 95% CI 1.12–3.76) as compared to low levels of both markers. In contrast, the HR was not significant in the combination of high CRP and low ADMA levels, as well as low CRP and high ADMA levels.ConclusionsSerum CRP, but not ADMA, levels were associated with the risk of metabolic syndrome. Nevertheless, the risk of metabolic syndrome could be predicted more reliably by considering these two markers together rather than CRP alone.