INTRAMYELINIC AND EXTRACELLULAR SPACES IN TRIETHYLTIN INTOXICATION
INTRAMYELINIC AND EXTRACELLULAR SPACES IN TRIETHYLTIN INTOXICATION
复制标题
三乙基锡中毒中的髓鞘内和细胞外空间
DOI：
10.1097/00005072-196810000-00003
复制
发表时间：
1968
影响因子：
3.2
通讯作者：
S. Levine
中科院分区：
文献类型：
--
作者：
Asao Herano;H. M. Zimmerman;S. Levine
其中回答。醋酸三乙基锡腹腔注射：腹腔注射醋酸三乙基锡1天后，髓鞘分裂均匀分布于包括视神经在内的中枢神经系统（图1）。一般来说，这些分裂是不规则的，没有任何可识别的内容，正如其他人所说明的那样（1,2），是由时期间线的分裂引起的。未观察到神经、神经胶质或血管的改变。细胞外间隙仍然狭窄。2和3天后，效果的程度和强度增加，但没有观察到其他变化。脑内植入：醋酸三乙基锡微丸植入1天后，中枢神经系统未见髓磷脂普遍分裂。这些改变局限于植入部位和相邻的胼胝体辐射。植入部位的中心由微球和坏死组织组成。从该点放射到白质，可见不同数量的细胞外、电子密集的血液性水肿液（图2）。水肿液的外观和位置与植入各种其他刺激物后观察到的水肿液基本相同(6)。在此时牺牲的其中一只动物的几个脑块中，在植入后第二天，在水肿的aa0中观察到罕见的，分散的局灶性髓内分裂，水肿的范围和严重程度沿白质束明显增加。分散的髓鞘在这些束中偶见髓鞘内分裂。此时，尽管个体动物和组织块之间存在差异，但改变后的组织的主要特征是细胞外水肿，分裂的意义相对较小。植入4天后，情况逆转，虽然细胞外水肿仍然存在，但髓内分裂占据了野的主要部分。分裂通常缺乏电子密度的内容，仍然局限于植入的半球。此时，在中心坏死区附近可发现巨噬细胞，并发现其他各种胶质和神经元反应，如其他植入实验(9)所见。脑内植入和腹腔注射：当两种给药途径同时使用时，效果简单相加。因此，双三乙基锡给药后1天，双脑半球和视神经出现广泛性分裂，植入物附近和相邻胼胝体辐射处出现局灶性细胞外水肿。在水肿区常见髓内分裂（图3）。在大多数情况下，髓内分裂仍然清晰（图2）。4、5)。第二天，双方水肿
RESULTS1. Triclhyltin Acetate Intraperitoneal Injection: One day after the intraperitonealinjection of triethyltin acetate, myelin splitting was secn evenly distributed throughout the areas of the central nervous system examined including the optic nerve (fig. 1). The splits were, in general, irregular, devoid of any discernible content and, as illustrated by others (1, 2), arose from the splitting of an interperiod line. Neu-ronal, glial or vascular changes were not observed. The extracellular spaces remained narrow. After 2 and 3 days, the extent and intensity of the effect increased but no other changes were observed. Intracerebral Implantation: One day after the implantation of pellets of triethyl-tin acetate, no generalized myelin splitting was present in the central nervous system. The alterations were confined to the site of implantation and the con-tiguous callosal radiation. The center of the implantation site was composed of the pellet and necrotic tissue. From that point and radiating into the white matter, various amounts of extracellular, electron-dense, hematogenous edema fluid were present (fig. 2). The appearance and location of the edema fluid were essentially identical to those observed after the implantation of a variety of other irritants (6). In a few blocks of the brain of one of the animals sacrificed at this time, rare, scattered focal intramyelinic splits were observed within the edematous aa0SBy the second day after implantation, the extent and severity of the edema had increased markedly along the white matter bundles. Scattered myelin sheaths within these bundles showed occasional intramyelinic splits. At this time, al-though differences between individual animals and tissue blocks existed, the predominant feature of thc altered tissue consisted of extracellular edema, and the splits were of relatively minor significance. Four days after implantation, the situation was reversed, and while extra-cellular edema was still present, the intramyelinic splits occupied the major portion of the field. The splits were generally devoid of electron-dense content and remained confined to the implanted hemisphere. At this time, macrophages could be found near the central necrotic area and various other glial and neuronal reactions, as seen in other implantation experiments (9), were found. Intracerebral Implantation and Interperitoneal Injection: When both routes of administration was utilized simultaneously, the effects were simply additive. Thus, one day after double triethyltin administration, there was generalized splittingin both hemispheres and optic nerves as well as focal extracellular edema near the implant and in the contiguous callosal radiation. Intramyelinic splits were commonly seen in the edematous areas (fig. 3). For the most part, the intramyelinic splits remained clear (figs. 4, 5). On the second day, both edema