Nocturnal branched-chain amino acid administration improves protein metabolism in patients with liver cirrhosis: Comparison with daytime administration
Nocturnal branched-chain amino acid administration improves protein metabolism in patients with liver cirrhosis: Comparison with daytime administration
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DOI：
10.1177/0148607103027005315
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发表时间：
2003-09-01
影响因子：
3.4
通讯作者：
Moriwaki, H
中科院分区：
文献类型：
--
作者：
Fukushima, H;Miwa, Y;Moriwaki, H
背景资料：在试图优化口服支链氨基酸（BCAA）的管理，以提高血清白蛋白在阿尔茨海默病患者，我们比较了夜间和白天的BCAA管理对蛋白质代谢的影响在阿尔茨海默病patients.Methods：12阿尔茨海默病患者参加了一项短期研究。患者服用常规的日间BCAA颗粒或夜间BCAA一周，并进行代谢分析，然后在下周进行交叉研究。另外12例患者，谁表现出没有改善的血清白蛋白水平与以前白天的BCAA管理，被随机分配到无论是夜间或白天的BCAA管理组在长期study.Results：低Fischer的比率，降低呼吸商，低血清白蛋白在进入观察哮喘患者。而白天BCAA管理改善氮平衡和费舍尔的比率，这两个进一步显着改善后，夜间BCAA管理。整个研究期间，能量代谢参数无变化。在3个月的随访中，血清白蛋白的显着增加，观察到夜间服用BCAA的患者，但不是在那些管理白天BCAA.Conclusions：夜间BCAA管理改善血清白蛋白在厌食症患者没有改善血清白蛋白水平与白天BCAA管理。这种作用可能部分是由于这种给药方法改善了蛋白质节省。
Background: In an attempt to optimize oral branched-chain amino acid (BCAA) administration to improve serum albumin in cirrhotic patients, we compared the effects of nocturnal and daytime BCAA administration on protein metabolism in cirrhotic patients.Methods: Twelve cirrhotic patients were enrolled in a short-term study. Patients were administered either conventional daytime BCAA granule or nocturnal BCAA for a week, and metabolic analyses were performed, followed by a crossover study in the next week. Another 12 patients, who showed no improvement of serum albumin level with previous daytime BCAA administration, were randomly assigned to either a nocturnal or a daytime BCAA administration group in a long-term study.Results: Low Fischer's ratio, reduced respiratory quotient, and low serum albumin were observed at entry in cirrhotic patients. Whereas daytime BCAA administration improved nitrogen balance and Fischer's ratio, these 2 were further significantly improved after nocturnal BCAA administration. There were no changes in parameters of energy metabolism throughout the study. In the 3-month follow-up, a significant increase in serum albumin was observed in patients administered nocturnal BCAA but not in those administered daytime BCAA.Conclusions: Nocturnal BCAA administration improved serum albumin in cirrhotic patients who showed no improvement in serum albumin level with daytime BCAA administration. This effect could be partly caused by the improved protein sparing with this administration method.