Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring
Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring
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DOI：
10.1007/s00394-004-0433-y
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发表时间：
2004-02-01
影响因子：
5
通讯作者：
Steegers-Theunissen, RPM
中科院分区：
文献类型：
--
作者：
Krapels, IPC;van Rooij, IALM;Steegers-Theunissen, RPM
背景感知。建议补充叶酸以预防口面裂（OFC）。然而，其他B族维生素也可能有益。本研究的目的是探讨母亲围产期膳食中维生素B1、B2、B3、B4、B6的摄入量与眶额囊炎发生的关系。方法206名非综合征型OFC患儿的母亲和203名对照组母亲在产后14个月左右填写一般情况调查表和食物频率调查表，作为围受孕期的代表。摄入排除已知的怀孕和哺乳期的母亲，那些谁报告说，改变了他们的饮食相比，围怀孕期，和母亲偶然叶酸补充剂使用围怀孕期，182 OFC母亲和173对照组的数据进行了分析。对数转换后，计算几何平均值（P5-P95）并进行组间比较。在随后的能量调整后，饮食B族维生素摄入量的五分位数被创建。结果OFC患儿母亲的维生素B1、烟酸和吡哆醇摄入量明显低于OFC患儿母亲。硫胺素（p = 0.04）和吡哆醇（p = 0.03）显示了随着膳食摄入量增加，OFC风险降低的趋势。仅在围孕期使用叶酸补充剂的女性中证明了风险降低。补充剂使用者倾向于食用富含B族维生素的饮食。结论围绝经期摄入硫胺素、烟酸和吡哆醇可能有助于预防OFC的发生。
Background Periconceptional. folic acid supplementation is suggested to prevent orofacial clefts (OFCs). Other B vitamins however may be beneficial as well. Aim of the study To investigate the maternal periconceptional dietary intake of thiamine, riboflavin, niacin, pyridoxine and cobalamin in association with the occurrence of OFC. Methods Two hundred and six mothers of a child with nonsyndromic OFC and 203 control mothers filled out a general questionnaire and a food frequency questionnaire around 14 months postpartum as a proxy for periconceptional. intake. After exclusion of known pregnant and lactating mothers, those who reported to have altered their diet compared to the periconceptional period, and mothers with incidental folic acid supplement use periconceptionally, data of 182 OFC mothers and 173 controls were analysed. After logarithmic transformation, geometric means (P5-P95) were calculated and compared between the groups. After subsequent adjustment for energy, quintiles of dietary B vitamin intake were created. Results The periconceptional intake of thiamine, niacin and pyridoxine was significantly lower in mothers of an OFC child. A trend towards risk reduction for OFC with increasing dietary intake was demonstrated for thiamine (p = 0.04) and pyridoxine (p = 0.03). Risk reductions were only demonstrated in women using folic acid supplements periconceptionally. Supplement users tended to consume a diet richer in B vitamins. Conclusions Periconceptional intake of thiamine, niacin and pyridoxine seems to contribute to the prevention of OFC.