Sarcopenia adversely impacts postoperative complications following resection or transplantation in patients with primary liver tumors.
Sarcopenia adversely impacts postoperative complications following resection or transplantation in patients with primary liver tumors.
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DOI：
10.1007/s11605-014-2680-4
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发表时间：
2015-02
影响因子：
3.2
通讯作者：
Pawlik, Timothy M.
中科院分区：
文献类型：
--
作者：
Valero, Vicente, III;Amini, Neda;Spolverato, Gaya;Weiss, Matthew J.;Hirose, Kenzo;Dagher, Nabil N.;Wolfgang, Christopher L.;Cameron, Andrew A.;Philosophe, Benjamin;Kamel, Ihab R.;Pawlik, Timothy M.
关键词：
肌肉减少症是患者虚弱的替代标志物，其估计个体患者的生理储备。我们试图研究肌肉减少症对原发性肝脏恶性肿瘤手术患者的短期和长期结局的影响。2000年至2013年期间在约翰霍普金斯医院接受肝切除或肝移植治疗HCC或ICC的96例患者符合入选标准。通过测量总腰大肌体积（TPV）和总腰大肌面积（TPA）评估肌肉减少症。评估了肌肉减少症对围手术期并发症和生存率的影响。平均年龄为61.9岁，大多数患者为男性（61.4%）。女性（23.3 cm 3/m）的平均校正TPV低于男性（34.9 cm 3/m）（P<0.01）; 47例患者（48.9%）有肌肉减少症。肌肉减少症患者的术后并发症发生率为40.4%，而非肌肉减少症患者的术后并发症发生率为18.4%（P=0.01）。值得注意的是，所有Clavien ≥3级并发症（n=11，23.4%）均发生在肌肉减少组。多因素分析显示，肌肉减少症是术后并发症的独立预测因素（OR=3.06）。肌肉减少症与长期生存率无关（HR=1.23; P=0.51）。通过TPV评估，肌肉减少是原发性肝脏恶性肿瘤手术干预后并发症的独立预测因素。
Sarcopenia is a surrogate marker of patient frailty that estimates the physiologic reserve of an individual patient. We sought to investigate the impact of sarcopenia on short- and long-term outcomes in patients having undergone surgical intervention for primary hepatic malignancies. Ninety-six patients who underwent hepatic resection or liver transplantation for HCC or ICC at the John Hopkins Hospital between 2000 and 2013 met inclusion criteria. Sarcopenia was assessed by the measurement of total psoas major volume (TPV) and total psoas area (TPA). The impact of sarcopenia on perioperative complications and survival was assessed. Mean age was 61.9 years and most patients were men (61.4 %). Mean adjusted TPV was lower in women (23.3 cm3/m) versus men (34.9 cm3/m) (P<0.01); 47 patients (48.9 %) had sarcopenia. The incidence of a postoperative complication was 40.4 % among patients with sarcopenia versus 18.4 % among patients who did not have sarcopenia (P=0.01). Of note, all Clavien grade ≥3 complications (n=11, 23.4 %) occurred in the sarcopenic group. On multivariable analysis, the presence of sarcopenia was an independent predictive factor of postoperative complications (OR=3.06). Sarcopenia was not associated with long-term survival (HR=1.23; P=0.51). Sarcopenia, as assessed by TPV, was an independent factor predictive of postoperative complications following surgical intervention for primary hepatic malignancies.
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DOI：
10.1016/j.jamcollsurg.2010.03.039
发表时间：
2010-08
影响因子：
5.2
作者：
Englesbe, Michael J.;Patel, Shaun P.;He, Kevin;Lynch, Raymond J.;Schaubel, Douglas E.;Harbaugh, Calista;Holcombe, Sven A.;Wang, Stewart C.;Segev, Dorry L.;Sonnenday, Christopher J.
通讯作者：
Sonnenday, Christopher J.
影响因子：
9
作者：
Nathan, Hari;Schulick, Richard D.;Pawlik, Timothy M.
通讯作者：
Pawlik, Timothy M.
影响因子：
19.7
作者：
Bonekamp, Susanne;Halappa, Vivek Gowdra;Kamel, Ihab R.
通讯作者：
Kamel, Ihab R.
影响因子：
3.5
作者：
Lang, Pierre-Olivier;Michel, Jean-Pierre;Zekry, Dina
通讯作者：
Zekry, Dina
影响因子：
19.7
作者：
Gowdra Halappa V;Corona-Villalobos CP;Bonekamp S;Li Z;Reyes D;Cosgrove D;Pawlik TM;Diaz LA;Bhagat N;Eng J;Geschwind JF;Kamel IR
通讯作者：
Kamel IR