Factors contributing to ribavirin-induced anemia
Factors contributing to ribavirin-induced anemia
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DOI：
10.1111/j.1440-1746.2004.03459.x
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发表时间：
2004-11-01
影响因子：
4.1
通讯作者：
Ishibashi, H
中科院分区：
文献类型：
--
作者：
Nomura, H;Tanimoto, H;Ishibashi, H
背景和目的：干扰素和利巴韦林联合治疗慢性丙型肝炎可导致溶血性贫血。进行这项研究，以确定的因素，利巴韦林引起的anemia.Methods：88例慢性丙型肝炎谁收到干扰素-α-2b（6 MU的剂量，肌肉注射给药24周，与利巴韦林口服给药的剂量为600毫克或800毫克参加了这项研究。观察到第2周时血红蛋白浓度降低≥ 2 g/dL，甚至在第2周后也显著低于
Background and Aim: Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia. This study was conducted to identify the factors contributing to ribavirin-induced anemia.Methods: Eighty-eight patients with chronic hepatitis C who received interferon-alpha-2b at a dose of 6 MU administered intramuscularly for 24 weeks in combination with ribavirin administered orally at a dose of 600 mg or 800 mg participated in the study. A hemoglobin concentration of = 2 g/dL decrease at week 2 was observed to be significantly lower even after week 2 than in patients with