Alcohol Consumption and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of More Than 1.9 Million Individuals From 38 Observational Studies
Alcohol Consumption and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of More Than 1.9 Million Individuals From 38 Observational Studies
复制标题
DOI：
10.2337/dc15-0710
复制
发表时间：
2015-09-01
期刊：
影响因子：
16.2
通讯作者：
Britton, Annie
中科院分区：
文献类型：
--
作者：
Knott, Craig;Bell, Steven;Britton, Annie
观察性研究表明，适度饮酒可以降低2型糖尿病的风险。除了提供现有文献的最新摘要，这项荟萃分析探讨了风险的降低是否可能是错误分类的产品。研究设计和方法进行了系统的搜索，确定研究报告的时间关联饮酒和2型糖尿病的风险。对出版的语言或日期没有任何限制。非英文出版物在必要时使用在线翻译工具进行翻译。使用分数多项式回归构建模型，以确定酒精摄入量和2型糖尿病之间的最佳拟合剂量-反应关系，并对性别和参照组相互作用进行先验检验。33项研究报告了传统的非当前饮酒类别，而5项研究报告了从不饮酒类别。相对于联合戒酒者，2型糖尿病风险的降低存在于所有酒精摄入水平
OBJECTIVEObservational studies indicate that moderate levels of alcohol consumption may reduce the risk of type 2 diabetes. In addition to providing an updated summary of the existing literature, this meta-analysis explored whether reductions in risk may be the product of misclassification bias.RESEARCH DESIGN AND METHODSA systematic search was undertaken, identifying studies that reported a temporal association between alcohol consumption and the risk of type 2 diabetes. No restrictions were placed upon the language or date of publication. Non-English publications were, where necessary, translated using online translation tools. Models were constructed using fractional polynomial regression to determine the best-fitting dose-response relationship between alcohol intake and type 2 diabetes, with a priori testing of sex and referent group interactions.RESULTSThirty-eight studies met the selection criteria, representing 1,902,605 participants and 125,926 cases of type 2 diabetes. A conventional noncurrent drinking category was reported by 33 studies, while five reported a never-drinking category. Relative to combined abstainers, reductions in the risk of type 2 diabetes were present at all levels of alcohol intake