Direct effect of insulin on secretion of insulin, glucagon, gastric inhibitory polypeptide, and gastrin during maintenance of normoglycemia.
Direct effect of insulin on secretion of insulin, glucagon, gastric inhibitory polypeptide, and gastrin during maintenance of normoglycemia.
复制标题
在维持正常血糖过程中，胰岛素对胰岛素、胰高血糖素、抑胃多肽和胃泌素的分泌有直接影响。
DOI：
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发表时间：
1978
影响因子：
5.8
通讯作者：
V. Go
中科院分区：
文献类型：
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作者：
F. Service;R. Nelson;A. Rubenstein;V. Go
在正常受试者中，通过输注胰岛素，同时血浆葡萄糖水平维持在正常空腹范围内（正葡萄糖钳夹），研究胰岛素对胰岛素（通过C肽测量）、胰高血糖素、胃抑制多肽和胃泌素分泌的直接影响。胰岛素诱导的低血糖导致循环胰高血糖素和胃抑制多肽增加，C肽减少，胃泌素水平无变化。与此相反，在正常葡萄糖钳夹过程中，发现胰岛素对胰高血糖素、C肽和胃泌素的分泌有直接抑制作用，但对胃抑制多肽的水平没有影响。
The direct effect of insulin on the secretion of insulin (as measured by C-peptide), glucagon, gastric inhibitory polypeptide, and gastrin was studied in normal subjects by infusing insulin while the plasma level of glucose was maintained in the normal fasting range (euglycemic clamp). Insulin-induced hypoglycemia resulted in increases in circulating glucagon and gastric inhibitory polypeptide, a decrease in C-peptide, and no change in gastrin levels. In contrast, during the euglycemic clamp, insulin was found to behave a direct suppressive effect on the secretion of glucagon, C-peptide, and gastrin, but no effect on levels of gastric inhibitory polypeptide.