The emerging theme of 3'UTR mRNA isoform regulation in reprogramming of cell metabolism.
The emerging theme of 3'UTR mRNA isoform regulation in reprogramming of cell metabolism.
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DOI：
10.1042/bst20221128
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发表时间：
2023-05
影响因子：
3.9
通讯作者：
Qiang Zhang;Bin Tian
中科院分区：
文献类型：
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作者：
Qiang Zhang;Bin Tian
mRNA的3'非翻译区（3'UTR）在基因表达的转录后调控中起关键作用。大多数真核生物蛋白质编码基因由于交替切割和多聚腺苷酸化（阿帕）而表达3'UTR同种型。细胞的3'UTR同种型表达谱在细胞增殖、分化和应激条件下发生变化。在这里，我们回顾了新出现的主题，在细胞代谢重编程中的3'UTR亚型的调节，重点是通过mTOR途径的细胞生长和自噬反应。我们讨论的调节事件，会聚在裂解因子I复合物，阿帕在3'UTR的主调节器，和最近的理解亚型特异性m6A修饰和内膜协会在确定差异代谢命运的3'UTR亚型。
The 3' untranslated region (3'UTR) of mRNA plays a key role in the post-transcriptional regulation of gene expression. Most eukaryotic protein-coding genes express 3'UTR isoforms owing to alternative cleavage and polyadenylation (APA). The 3'UTR isoform expression profile of a cell changes in cell proliferation, differentiation, and stress conditions. Here, we review the emerging theme of regulation of 3'UTR isoforms in cell metabolic reprogramming, focusing on cell growth and autophagy responses through the mTOR pathway. We discuss regulatory events that converge on the Cleavage Factor I complex, a master regulator of APA in 3'UTRs, and recent understandings of isoform-specific m6A modification and endomembrane association in determining differential metabolic fates of 3'UTR isoforms.