SOX5 predicts poor prognosis in lung adenocarcinoma and promotes tumor metastasis through epithelial-mesenchymal transition.
SOX5 predicts poor prognosis in lung adenocarcinoma and promotes tumor metastasis through epithelial-mesenchymal transition.
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SOX5预测肺腺癌的不良预后并通过上皮间质转化促进肿瘤转移
DOI：
10.18632/oncotarget.22443
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发表时间：
2018-02-16
期刊：
影响因子：
--
通讯作者：
Li W
中科院分区：
文献类型：
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作者：
Chen X;Fu Y;Xu H;Teng P;Xie Q;Zhang Y;Yan C;Xu Y;Li C;Zhou J;Ni Y;Li W
肺癌是全球癌症相关死亡的主要原因。上皮间质转化（EMT）促进肺癌的进展和转移，尤其是在肺腺癌中。已知性别决定区Y盒蛋白5（SOX 5）刺激各种癌症的进展。在这里，我们使用免疫组织化学分析，揭示SOX 5水平增加，在90例肺腺癌患者。SOX 5在肺腺癌和非肿瘤组织中的高表达与患者的不良预后相关。抑制SOX 5表达可减弱肺癌细胞的转移和进展，而过表达SOX 5可通过EMT加速肺腺癌的进展和转移。体内斑马鱼异种移植癌症模型也显示，SOX 5敲低后肺癌细胞增殖和转移减少。我们的研究结果表明，SOX 5促进肺腺癌的致瘤性，并可能成为一种新的诊断和预后的疾病标志物。
Lung cancer is the leading cause of cancer-related death worldwide. Epithelial-mesenchymal transition (EMT) promotes lung cancer progression and metastasis, especially in lung adenocarcinoma. Sex determining region Y-box protein 5 (SOX5) is known to stimulate the progression of various cancers. Here, we used immunohistochemical analysis to reveal that SOX5 levels were increased in 90 lung adenocarcinoma patients. The high SOX5 expression in lung adenocarcinoma and non-tumor counterparts correlated with the patients’ poor prognosis. Inhibiting SOX5 expression attenuated metastasis and progression in lung cancer cells, while over-expressing SOX5 accelerated lung adenocarcinoma progression and metastasis via EMT. An in vivo zebrafish xenograft cancer model also showed SOX5 knockdown was followed by reduced lung cancer cell proliferation and metastasis. Our results indicate SOX5 promotes lung adenocarcinoma tumorigenicity and can be a novel diagnosis and prognosis marker of the disease.