Life Without Dreams: Muscarinic Receptors Are Required to Regulate REM Sleep in Mice

Life Without Dreams: Muscarinic Receptors Are Required to Regulate REM Sleep in Mice
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没有梦想的生活:调节小鼠快速眼动睡眠需要毒蕈碱受体

DOI:
10.1016/j.celrep.2018.08.044
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发表时间:
2018
期刊:
影响因子:
8.8
通讯作者:
Hayashi Yu
Hayashi Yu
中科院分区:
生物学1区
文献类型:
--
作者:
Kashiwagi Mitsuaki;Hayashi Yu

文献摘要

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哺乳动物睡眠包括REM和NREM阶段,但其调节机制尚不清楚。在本期的《细胞报告》中,Niwa et al.(2018)全面敲除小鼠的胆碱能受体,发现毒蕈碱信号对REM睡眠至关重要,对NREM睡眠可能也很重要。
Mammalian sleep comprises REM and NREM stages, but the regulation mechanisms are unclear. In this issue ofCell Reports, Niwa et al. (2018) comprehensively knocked out cholinergic receptors in mice and found that muscarinic signaling is crucial for REM sleep and possibly important for NREM sleep.