Airways obstruction, chronic expectoration, and rapid decline of FEV(1) in smokers are associated with increased levels of sputum neutrophils
Airways obstruction, chronic expectoration, and rapid decline of FEV(1) in smokers are associated with increased levels of sputum neutrophils
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DOI：
10.1136/thx.51.3.267
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发表时间：
1996-03-01
期刊：
影响因子：
10
通讯作者：
Maestrelli, P
中科院分区：
文献类型：
--
作者：
Stanescu, D;Sanna, A;Maestrelli, P
背景 - 吸烟可能导致气道炎症和肺功能受损。为了确定气道炎症的类型和程度与肺功能下降之间的关系，对吸烟者和戒烟者痰中的白细胞进行了检查。方法 - 对 46 名吸烟者和戒烟者进行了肺功能测试和问卷调查，他们的中位年龄为 64 岁（25%；75% 百分位 62；66），吸烟史为 40.1（31.7；53）包年。 15 年随访期结束。通过吸入高渗盐水诱导痰液，并对细胞离心涂片制剂进行白细胞分类计数。 结果 - 38 名受试者 (78%) 获得了足够的痰液样本。一秒用力呼气量 (FEV(1)) 与肺活量 (VC) 之比为 67.1 (60; 72)%，FEV(1) 年下降量为 19.4 (12; 30) ml/年。气道阻塞的受试者 (FEV(1)/VC
Background - Smoking may cause inflammation of the airways and impairment of lung function. To determine the relationship between the type and degree of airways inflammation and the decline in lung function, leucocytes in the sputum of smokers and ex-smokers were examined.Methods - Forty six smokers and exsmokers of median age 64 years (25%; 75% percentiles 62; 66) with a smoking history of 40.1 (31.7; 53) pack years were studied with lung function tests and a questionnaire at the end of a 15 year follow up period. Sputum was induced by inhalation of hypertonic saline and differential leucocyte counts were performed on cytospin preparations.Results - Adequate sputum samples were obtained in 38 subjects (78%). The ratio of forced expiratory volume in one second (FEV(1)) to vital capacity (VC) was 67.1 (60; 72)% and the annual decline in FEV(1) was 19.4 (12; 30) ml/year. Subjects with airways obstruction (FEV(1)/VC