Motor and non-motor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques
Motor and non-motor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques
复制标题
DOI：
10.1111/j.1460-9568.2010.07151.x
复制
发表时间：
2010-04-01
影响因子：
3.4
通讯作者：
Hoshi, Eiji
中科院分区：
文献类型：
--
作者：
Hashimoto, Masashi;Takahara, Daisuke;Hoshi, Eiji
在尾侧部分的背侧运动前皮质的猕猴（F2区），解剖学和生理学的研究已经确定了两个rostrocaudally独立的部门。吻侧区（F2 r）位于弓状沟内侧，尾侧区（F2 c）位于上级中央前窝外侧。在这里，我们研究了从小脑到F2 r和F2c的投射的起源部位。我们在猕猴中应用了嗜神经病毒狂犬病病毒CVS-11的逆行跨突触转运。狂犬病注射到F2 r或F2c三天后，神经元标记主要在对侧半球的小脑深核。注射F2 r后，标记细胞主要分布在齿状核的尾腹侧部，而注射F2 c后标记的细胞分布在齿状核的吻背侧部、间位核和顶核中。狂犬病注射后4天，浦肯野细胞密集标记在小脑皮质的外侧部分。注射F2 r后，浦肯野细胞标记仅限于脚I和II，而注射F2c后观察到的标记广泛位于小叶III至VIII，包括脚I和II。这些结果表明，F2c比F2 r接收来自小脑更广泛区域的输入，并且小脑深核和小脑皮质的不同部分向F2 r和F2c发送主要投射，这表明F2c和F2 r可能受到小脑的特定影响。
In the caudal part of the dorsal premotor cortex of macaques (area F2), both anatomical and physiological studies have identified two rostrocaudally separate sectors. The rostral sector (F2r) is located medial to the genu of the arcuate sulcus, and the caudal sector (F2c) is located lateral to the superior precentral dimple. Here we examined the sites of origin of projections from the cerebellum to F2r and F2c. We applied retrograde transsynaptic transport of a neurotropic virus, CVS-11 of rabies virus, in macaque monkeys. Three days after rabies injections into F2r or F2c, neuronal labeling was found in the deep cerebellar nuclei mainly of the contralateral hemisphere. After the F2r injection, labeled cells were distributed primarily in the caudoventral portion of the dentate nucleus, whereas cells labeled after the F2c injection were distributed in the rostrodorsal portion of the dentate nucleus, and in the interpositus and fastigial nuclei. Four days after rabies injections, Purkinje cells were densely labeled in the lateral part of the cerebellar cortex. After the F2r injection, Purkinje cell labeling was confined to Crus I and II, whereas the labeling seen after the F2c injection was located broadly from lobules III to VIII, including Crus I and II. These results have revealed that F2c receives inputs from broader areas of the cerebellum than F2r, and that distinct portions of the deep cerebellar nuclei and the cerebellar cortex send major projections to F2r and F2c, suggesting that F2c and F2r may be under specific influences of the cerebellum.