Frontal and Temporal Structural Connectivity Is Associated with Social Communication Impairment Following Traumatic Brain Injury.
Frontal and Temporal Structural Connectivity Is Associated with Social Communication Impairment Following Traumatic Brain Injury.
复制标题
额叶和颞叶结构连接与创伤性脑损伤后的社交沟通障碍有关。
DOI：
10.1017/s1355617716000539
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Duff,MelissaC
中科院分区：
文献类型：
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作者：
Rigon,Arianna;Voss,MichelleW;Turkstra,LynS;Mutlu,Bilge;Duff,MelissaC
虽然创伤性脑损伤（TBI）可以导致沟通障碍，但迄今为止，很少有工作研究TBI患者的社会沟通技能和结构性脑完整性之间的关系。本研究的目的是调查轻度至重度TBI患者自我和他人感知的沟通问题与白色完整性之间的关联。方法44名个体（TBI=24）和他们经常沟通的人，以及人口统计学匹配的正常健康对照（NC）和他们经常沟通的伙伴，分别被管理，La-Trobe沟通问卷自我表格（LCQ-SELF）和其他表格（LCQ-OTHER）。此外，收集扩散张量成像数据，并提取每个叶在两个半球的分数各向异性（FA）措施。结果在TBI组，但不是在NC组，参与者谁被认为是他们的亲密的其他人有更多的沟通问题有较低的FA在左额叶和颞叶（p<0.01），但在其他脑区无此现象。结论额颞白色物质微结构完整性与成人TBI的社会沟通能力有关。这一发现有助于我们理解TBI后导致沟通障碍的机制，并可以为新的神经调节疗法和诊断工具的开发提供信息。(JINS，2016，22，705-716）
ObjectivesAlthough it has been well documented that traumatic brain injury (TBI) can result in communication impairment, little work to date has examined the relationship between social communication skills and structural brain integrity in patients with TBI. The aim of the current study was to investigate the association between self- and other-perceived communication problems and white matter integrity in patients with mild to severe TBI.MethodsForty-four individuals (TBI=24) and people with whom they frequently communicate, as well as demographically matched normal healthy comparisons (NC) and their frequent communication partners, were administered, respectively, the La-Trobe Communication Questionnaire Self form (LCQ-SELF) and Other form (LCQ-OTHER). In addition, diffusion tensor imaging data were collected, and fractional anisotropy (FA) measures were extracted for each lobe in both hemispheres.ResultsWithin the TBI group, but not within the NC group, participants who were perceived by their close others as having more communication problems had lower FA in the left frontal and temporal lobes (p<.01), but not in other brain regions.ConclusionsFrontotemporal white matter microstructural integrity is associated with social communication abilities in adults with TBI. This finding contributes to our understanding of the mechanisms leading to communication impairment following TBI and can inform the development of new neuromodulation therapies as well as diagnostic tools. (JINS, 2016, 22, 705–716)