Role of leptin in immunity.
Role of leptin in immunity.
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DOI：
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发表时间：
2007-02
影响因子：
24.1
通讯作者：
Q. Lam;Liwei Lu
中科院分区：
文献类型：
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作者：
Q. Lam;Liwei Lu
瘦素是脂肪细胞产生的一种蛋白质激素，长期以来一直被认为具有调节代谢、神经内分泌等生理功能。在感染和炎症过程中瘦素产生增加以及瘦素信号缺陷小鼠免疫应答失调的早期发现为瘦素参与免疫应答提供了强有力的证据。最近的数据已经确定了瘦素在免疫中的调节功能类似于促炎细胞因子的功能，而基因靶向研究也证明了瘦素在调节造血和淋巴细胞生成中的重要作用。此外，越来越多的证据表明，瘦素参与各种自身免疫性疾病的发病机制。本文就瘦素在免疫中的作用以及瘦素信号通路在调节免疫稳态和自身免疫发病机制中的作用作一综述。
Leptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis.