SYNOVIUM AS A SOURCE OF INTERLEUKIN 6 INVITRO - CONTRIBUTION TO LOCAL AND SYSTEMIC MANIFESTATIONS OF ARTHRITIS
SYNOVIUM AS A SOURCE OF INTERLEUKIN 6 INVITRO - CONTRIBUTION TO LOCAL AND SYSTEMIC MANIFESTATIONS OF ARTHRITIS
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DOI：
10.1172/jci113921
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发表时间：
1989-02-01
影响因子：
15.9
通讯作者：
LOTZ, M
中科院分区：
文献类型：
--
作者：
GUERNE, PA;ZURAW, BL;LOTZ, M
滑膜炎症通常与全身性变化相关，如急性期蛋白水平升高和高丙种球蛋白血症，这不能用滑液和滑膜细胞分泌物中描述的细胞因子来解释。白细胞介素6（IL-6）最近被鉴定为多种炎症反应的介质。这种细胞因子促进T和B淋巴细胞生长和分化，以及急性期蛋白质合成。因此，我们研究了IL-6生产的人滑膜细胞和其存在的滑液。在体外，滑膜细胞自发释放IL-6，IL-1和肿瘤坏死因子-α增加了IL-6的释放。滑膜细胞来源的IL-6活性能够诱导杂交瘤-浆细胞瘤增殖，以及免疫球蛋白和急性期蛋白的合成。不同关节病患者的滑液中含有IL-6活性，但炎性关节病中IL-6活性高于骨关节炎。这些结果表明，滑膜细胞是IL-6的有效来源，其可促成炎性关节病的重要表现。
Synovial inflammation is often associated with systemic changes, such as increased levels of acute phase proteins and hypergammaglobulinemia, which cannot be explained by the cytokines described in synovial fluids and synoviocyte secretions. Interleukin 6 (IL-6) has recently been characterized as a mediator of multiple inflammatory responses. This cytokine promotes T and B lymphocyte growth and differentiation, and acute phase protein synthesis. We therefore examined IL-6 production by human synoviocytes and its presence in synovial fluids. In vitro, synoviocytes spontaneously released IL-6, which was increased by IL-1 and tumor necrosis factor-.alpha.. Synoviocyte-derived IL-6 activity was able to induce hybridoma-plasmacytoma proliferation, and immunoglobulin and acute-phase protein synthesis. The synovial fluids from patients with diverse arthropathies contained IL-6 activity, but higher levels were present in inflammatory arthropathies than in osteoarthritis. These results demonstrate that synoviocytes are a potent source of IL-6, which can contribute to important manifestations of inflammatory arthropathies.