Association between schizophrenia symptoms and neurocognition on mobility in older adults with schizophrenia.
Association between schizophrenia symptoms and neurocognition on mobility in older adults with schizophrenia.
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DOI：
10.1080/13607863.2014.903467
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发表时间：
2014
影响因子：
3.4
通讯作者：
Vinogradov S
中科院分区：
文献类型：
--
作者：
Leutwyler H;Hubbard E;Jeste D;Miller B;Vinogradov S
目的：与没有严重精神疾病的人相比，患有精神分裂症的老年人出现与衰老相关的问题（如行动能力差）的速度更快。活动能力的减少导致健康状况不佳。神经认知功能受损和精神症状是精神分裂症的主要方面。本研究的目的是确定老年精神分裂症患者神经认知障碍和精神分裂症症状与活动能力之间的关系。方法：对46例老年精神分裂症患者进行横断面研究。评估参与者的神经认知功能（matrix Consensus Cognitive Battery）、精神症状（Positive and Negative Syndrome Scale或PANSS）和活动能力（Timed Get Up and Go或TGUG测试）。采用Pearson's双变量相关（双尾）和同步回归模型。结果：在双变量相关和多变量回归分析中，阴性症状的严重程度越低、处理测试的速度越快，TGUG时间越快（p< 0.05）。结论：我们的数据表明，较低的阴性症状和更快的加工速度对老年精神分裂症患者的活动能力有积极影响。对这一人群的活动干预需要针对神经认知障碍和精神分裂症症状，以获得最佳效果。
Objectives:Older persons with schizophrenia develop problems associated with aging, such as poor mobility, at more rapid rates than people without serious mental illness. Decrements in mobility contribute to poor health outcomes. Impaired neurocognitive function and psychiatric symptoms are central aspects of schizophrenia. The purpose of this study was to determine the association between neurocognitive impairment and schizophrenia symptoms to mobility in older adults with schizophrenia.Methods:A cross-sectional study with 46 older adults with schizophrenia. Participants were assessed on neurocognitive function (MATRICS Consensus Cognitive Battery), psychiatric symptoms (Positive and Negative Syndrome Scale or PANSS), and mobility (Timed Get Up and Go or TGUG test). Pearson's bivariate correlations (two-tailed) and a simultaneous regression model were used.Results:Lower severity of negative symptoms and faster speed of processing tests were associated with faster TGUG time in bivariate correlations and multivariate regression analyses (p< .05).Conclusion:Our data suggest that lower negative symptoms and faster speed of processing positively impact mobility in older patients with schizophrenia. Mobility interventions for this population need to target neurocognitive impairment and schizophrenia symptoms for optimal results.
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DOI：
10.1111/j.1532-5415.2004.52601.x
发表时间：
2004-12-01
影响因子：
6.3
作者：
Bartels, SJ
通讯作者：
Bartels, SJ
影响因子：
2.5
作者：
Leutwyler H;Hubbard EM;Jeste DV;Miller B;Vinogradov S
通讯作者：
Vinogradov S
影响因子：
6.6
作者：
Jeste, Dilip V.;Wolkowitz, Owen M.;Palmer, Barton W.
通讯作者：
Palmer, Barton W.
影响因子：
7
作者：
Kilbourne, Amy M.;Morden, Nancy E.;Blow, Frederic C.
通讯作者：
Blow, Frederic C.
影响因子：
--
作者：
Druss, BG;Bradford, WD;Krumholz, HM
通讯作者：
Krumholz, HM