Feline leukaemia virus: protective immunity is mediated by virus-specific cytotoxic T lymphocytes
Feline leukaemia virus: protective immunity is mediated by virus-specific cytotoxic T lymphocytes
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DOI：
10.1046/j.1365-2567.2000.00089.x
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发表时间：
2000-09-01
期刊：
影响因子：
6.4
通讯作者：
Jarrett, O
中科院分区：
文献类型：
--
作者：
Flynn, JN;Hanlon, L;Jarrett, O
猫白血病病毒(FeLV)核酸疫苗免疫家猫可在不诱导抗病毒抗体的情况下对病毒血症和潜伏期的形成提供保护。(1)为了确定细胞免疫对控制病毒复制和从宿主清除病毒的贡献，比较了疫苗保护、一过性病毒感染和持续病毒感染猫的FeLV特异性细胞毒性T淋巴细胞(CTL)反应。疫苗免疫与外周血液和淋巴器官中检测到的针对FeLV Gag/Pro和Env抗原的病毒特异性效应物CTL水平高于未接种疫苗的持续病毒流行的对照猫(P<；0.001)。同样，在暴露于FeLV后恢复的一过性病毒感染猫中也观察到更高水平的病毒特异性CTL。在控制感染的猫中，对Gag/Pro抗原的识别显著高于对Env抗原的识别。这是第一份报告，强调了病毒特异性CTL在决定接种疫苗的猫或从FeLV暴露中自然恢复的猫中确定FeLV感染的结果方面具有非常重要的作用。
Feline leukaemia virus (FeLV) nucleic acid vaccination of domestic cats affords protection against viraemia and the development of latency without inducing antiviral antibodies.(1) To determine the contribution of cell-mediated immunity to the control of virus replication and clearance from the host, FeLV-specific cytotoxic T lymphocyte (CTL) responses were compared in vaccine-protected, transiently viraemic, and persistently viraemic cats. Vaccinal immunity was associated with the detection of higher levels of virus-specific effector CTL in the peripheral blood and lymphoid organs to FeLV Gag/Pro and Env antigens than those observed in unvaccinated control, persistently viraemic cats (P < 0.001). Likewise, higher levels of virus-specific CTLs were also observed in transiently viraemic cats which recovered following exposure to FeLV. In cats that controlled their infection, recognition of Gag/Pro antigens was significantly higher than the recognition of Env antigens. This is the first report highlighting the very significant role that virus-specific CTL have in determining the outcome of FeLV infection in either vaccinated cats or cats recovering naturally from FeLV exposure.